吉首大学学报（自然科学版）2026，Vol.47Issue(3)：33-40,49,9.DOI:10.13438/j.cnki.jdzk.2026.03.006
博落回内生真菌Penicillium turbatum的次级代谢产物
Secondary Metabolites of Endophytic Fungus Penicillium turbatum from Macleaya cordata(Willd.)R.Br.
摘要
Abstract
In order to research the secondary metabolitesof the endophytic fungus Penicillium turbatum from Bolehui,the fermentation was carried out using a potato glucose liquid medium.Comprehensive chromatographic methods such as HP20 macroporous resin,MCI GEL CHP20P macroporous resin chro-matography,and semi-preparative HPLC were employed to separate and purify the metabolites.On the basis of that,the antibacterial activities of the metabolites against five types of bacteria were further in-vestigated.The results showed that a total of 11 monomeric compounds were isolated,namely penicillic acid,dihydropenicillic acid,orcinol,orsellinic acid,1H-Indole-3-carbaldehyde,Methyl Indole-3-acetate,4,4'-dihydroxybenzophenone,4-(2-hydroxyethyl)phenol,3-methoxy-4-methyl-3,5-dihydro-1H-pyrrol-2-one,guanosine,and adenosine.The 11 compounds were obtained from Penicillium turbatum for the first time.Penicillic acid has certain inhibitory effect on Chromobacterium violaceum,Escherichia coli,Bacil-lus subtilis and Staphylococcus aureus,minimum inhibitory concentration values were 25,50,100 and 100 mg/L respectively.Dihydropenicillic acid has certain inhibitory effect on Staphylococcus aureus,and its minimum inhibitory concentration value is 100 mg/L.关键词
内生真菌/Penicillium turbatum/次级代谢产物/最小抑菌浓度Key words
endophytic fungus/Penicillium turbatum/secondary metabolites/minimum inhibitory concen-tration分类
化学化工引用本文复制引用
郑牧垚,陈俊,殷智超,闵长莉,汪学军..博落回内生真菌Penicillium turbatum的次级代谢产物[J].吉首大学学报（自然科学版）,2026,47(3):33-40,49,9.基金项目
国家自然科学基金资助项目(31100019) （31100019）
微生物代谢全国重点实验室开放课题(MMLKF26-42) （MMLKF26-42）
皖西学院高层次人才科研启动经费项目(WGKQ2026024,WGKQ2022026) （WGKQ2026024,WGKQ2022026）
