临床神经病学杂志2026，Vol.39Issue(3)：227-233,7.
突触可塑性与Alzheimer's病
Synaptic plasticity and Alzheimer's disease
摘要
Abstract
Alzheimer's disease(AD)is a complex neurodegenerative disease characterized by impairments in learning and memory.The pathologic changes of AD include the deposition of senile plaques formed by amyloid-β protein and neurofibrillary tangles composed of excessive phosphorylation tau protein.Synaptic dysfunction in AD occurs prior to the formation of amyloid plaque deposition and neurofibrillary tangles and is positively correlated with cognitive impairment.This review will summarize the critical role of synaptic plasticity in the pathogenesis of AD,elucidating how synaptic plasticity may serve as a therapeutic target of AD,thereby providing new insights into the pathogenesis and interventions for AD.关键词
Alzheimer's病/突触可塑性/N-甲基-D-天冬氨酸受体/α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体/治疗靶点Key words
Alzheimer's disease/synaptic plasticity/N-methyl-D-aspartic acid receptor/α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors/therapeutic target分类
医药卫生引用本文复制引用
俞希,朱晓蕾..突触可塑性与Alzheimer's病[J].临床神经病学杂志,2026,39(3):227-233,7.基金项目
江苏省自然科学基金面上项目(BK20231120) （BK20231120）
南京市卫生科技发展重点项目(ZKX22025) （ZKX22025）
