南京中医药大学学报2026，Vol.42Issue(6)：799-806,8.DOI:10.14148/j.issn.1672-0482.2026.0799
从"主客浑受"辨治慢性胃炎"炎癌转化"
Differentiation and Treatment of Chronic Gastritis"Inflammation-Cancer Transformation"Based on the Theory of"Muddy Between Host and Guest"
摘要
Abstract
The theory of"muddy between host and guest"was proposed by Xue Shengbai to characterize the pathogenesis of dampness-heat pathogens penetrating the nutrient-blood phase and intermingling with blood vessels.The"inflammation-cancer trans-formation"of chronic gastritis is a complex process evolving from non-resolving inflammation to gastric cancer,and its pathogenetic evolution aligns with the features of"muddy between host and guest",that is,deficient healthy qi with stubborn entrenchment of patho-genic factors.Spleen-stomach deficiency constitutes the root cause,with internal retention of dampness-heat.Dampness obstructs qi movement and heat scorches to generate stasis;these three factors intermingle inseparably,accumulate and transform,ultimately form-ing the state of"muddy between host and guest".Prolonged retention of pathogenic factors covertly consumes healthy qi,leading to re-peated gastric mucosal injury and aberrant repair,which gradually progresses to atrophy,intestinal metaplasia,dysplasia,and even car-cinogenesis.Treatment adheres to the general principle of"separating host and guest",dynamically capturing the pathogenetic evolu-tion,and flexibly applying the method of supporting healthy qi and eliminating pathogens.Through measures such as strengthening the spleen and consolidating the root,clearing heat and resolving dampness,and resolving stasis and unblocking collaterals,the entangled state of dampness,heat,and stasis is resolved.The aim is to halt disease progression and reverse precancerous lesions,thereby provid-ing a theoretical basis and clinical rationale for the prevention and treatment of this disease with traditional Chinese medicine.关键词
主客浑受/慢性胃炎/炎癌转化/正虚邪客/湿热瘀结Key words
muddy between host and guest/chronic gastritis/inflammation-cancer transformation/healthy qi deficiency with patho-gen retention/dampness-heat with stasis accumulation分类
医药卫生引用本文复制引用
闫海琳,徐婧,张涵灵,吕文亮..从"主客浑受"辨治慢性胃炎"炎癌转化"[J].南京中医药大学学报,2026,42(6):799-806,8.基金项目
湖北省自然科学基金-中医药创新发展联合资助项目(2024AFD321) （2024AFD321）
国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
