南京中医药大学学报2026，Vol.42Issue(6)：916-924,9.DOI:10.14148/j.issn.1672-0482.2026.0916
温肾化瘀安冲方治疗肾阳虚痰湿血瘀型多囊卵巢综合征的临床研究
Clinical Study on the Effect of Wenshen Huayu Anchong Recipe on Polycystic Ovary Syndrome of Kidney Yang Deficiency,Phlegm-Dampness,and Blood Stasis Pattern
摘要
Abstract
OBJECTIVE To evaluate the effects of Wenshen Huayu Anchong Recipe(WSAR)on spontaneous ovulation and menstrual recovery in patients with polycystic ovary syndrome(PCOS)characterized by kidney yang deficiency,phlegm-dampness,and blood stasis pattern.METHODS From April 2023 to February 2025,a total of 64 women with kidney yang deficiency,phlegm-dampness,and blood stasis pattern PCOS who visited the Traditional Chinese Medicine Gynecology Clinic of Jiangxi University of Chi-nese Medicine Affiliated Hospital were enrolled.Participants were randomly assigned,using a random number table,to the treatment group(n=32)or the control group(n=32).The treatment group received the WSAR,while the control group received a placebo.Both groups were treated for 3 months,with a 1-month follow-up after treatment.During the study,3 patients in the treatment group and 7 patients in the control group withdrew.Changes in traditional Chinese medicine syndrome scores,anxiety,and depression(HADS),sexual function(FSFI),and quality of life(PCOSQ)were evaluated before and after treatment.Clinical manifestations of hyperandrogen-ism,including hirsutism,acne,and hair loss,were also assessed.Serum sex hormone levels[follicle-stimulating hormone(FSH),lutein-izing hormone(LH),estradiol(E2),prolactin(PRL),and total testosterone(T)]were measured using ELISA;fasting blood glucose(FBG),total cholesterol(TC),triglycerides(TG),high-density lipoprotein(HDL-C),and low-density lipoprotein(LDL-C)were measured by en-zymatic assay;fasting insulin(FINS)was measured by chemiluminescence immunoassay(CLIA),and the homeostasis model assessment of insulin resistance(HOMA-IR)was calculated.Adverse events were monitored during treatment,and spontaneous ovulation was as-sessed after treatment.RESULTS After 3 months of treatment,the treatment group showed significant improvement from baseline in TCM syndrome score,menstrual cycle length,acne score,LH,LH/FSH ratio,T,FINS,HOMA-IR,PCOSQ,and FSFI scores(P<0.01),whereas no significant changes were observed in the control group.Between-group comparisons indicated that the treatment group had a significantly higher monthly spontaneous ovulation rate and significantly higher PCOSQ and FSFI scores than the control group(P<0.05,P<0.01).Additionally,the treatment group had significantly lower TCM syndrome score,menstrual cycle length,acne score,LH,LH/FSH ratio,T,FINS,and HOMA-IR compared with the control group(P<0.05,P<0.01).No obvious adverse reactions were observed in either group during treatment.CONCLUSION The WSAR effectively increases the spontaneous ovulation rate in women with PCOS characterized by kidney yang deficiency,phlegm-dampness,and blood stasis pattern,while improving serum hormone lev-els,reducing traditional Chinese medicine syndrome scores,alleviating insulin resistance,enhancing quality of life,and demonstrating good safety.关键词
多囊卵巢综合征/温肾化瘀安冲方/自主排卵/随机对照试验/中医证候评分/胰岛素抵抗/胰岛素抵抗指数Key words
polycystic ovary syndrome/Wenshen Huayu Anchong Recipe/spontaneous ovulation/randomized controlled trial/tradi-tional Chinese medicine syndrome score/insulin resistance/insulin resistance index分类
医药卫生引用本文复制引用
漆宇琳,胡雨珊,梁瑞宁..温肾化瘀安冲方治疗肾阳虚痰湿血瘀型多囊卵巢综合征的临床研究[J].南京中医药大学学报,2026,42(6):916-924,9.基金项目
江西省科技厅"揭榜挂帅"项目(20223BBG71012) （20223BBG71012）
江西省科学技术厅重点研发计划(20181ACG70016) （20181ACG70016）
中医女性生殖健康及相关疾病研究与转化江西省重点实验室(2024SSY06311) （2024SSY06311）
梁瑞宁全国名老中医药专家传承工作室建设项目(国中医药人教函[2022]75号) （国中医药人教函[2022]75号）
江西省中医月经病临床研究基地(赣中医科教[2020]6号) （赣中医科教[2020]6号）
江西中医药大学科技创新团队(CXTD22013) （CXTD22013）
