南京中医药大学学报2026，Vol.42Issue(6)：941-954,14.DOI:10.14148/j.issn.1672-0482.2026.0941
植物来源纳米囊泡在炎症性疾病治疗中的研究进展
Research Progress on Plant-Derived Nanovesicles in the Treatment of Inflammatory Diseases
摘要
Abstract
Inflammatory diseases are a group of disorders characterized by aberrant activation,chronic persistence,or impaired resolution of inflammatory responses as key pathological features.Current anti-inflammatory drugs are limited by obvious adverse ef-fects after long-term use,a high risk of immunosuppression,relatively narrow therapeutic targets,and substantial interindividual vari-ability in efficacy.Plant-derived nanovesicles(PDNVs)have attracted increasing attention in the intervention of inflammatory diseases owing to their broad availability,good biocompatibility,structural stability,and intrinsic enrichment of diverse bioactive components,in-cluding lipids,proteins,nucleic acids,and secondary metabolites.These properties enable PDNVs to participate in inflammatory regu-lation through multi-target synergistic effects.This review systematically summarizes the compositional characteristics,functional ad-vantages,and research progress of PDNVs in inflammatory diseases,including inflammatory bowel disease,skin inflammation,osteoar-thritis,neurodegenerative diseases,acute lung injury,and acute kidney injury.Furthermore,the potential mechanisms and translational challenges of PDNVs from different plant sources are discussed,with the aim of providing a reference for in-depth mechanistic studies and preclinical development of PDNVs.关键词
植物来源纳米囊泡/炎症性疾病/抗炎机制/炎症性肠病/皮肤炎症/骨关节炎/神经退行性疾病/急性肺损伤/急性肾损伤Key words
plant-derived nanovesicles/inflammatory diseases/anti-inflammatory mechanisms/inflammatory bowel disease/skin inflammation/osteoarthritis/neurodegenerative diseases/acute lung injury/acute kidney injury分类
医药卫生引用本文复制引用
于铵萍,张路唱,谭舒童,高佳,范文培,王越,严然..植物来源纳米囊泡在炎症性疾病治疗中的研究进展[J].南京中医药大学学报,2026,42(6):941-954,14.基金项目
中国药科大学国家天然药物重点实验室专项研究基金(SKLNMZZ2024JS36) （SKLNMZZ2024JS36）
