药学研究2026，Vol.45Issue(5)：542-551,10.DOI:10.13506/j.cnki.jpr.2026.05.010
姜黄素及其衍生物在急性髓系白血病治疗中的研究进展
Research progress of curcumin and its derivatives in treatment of acute myeloid leukemia
摘要
Abstract
Acute myeloid leukemia(AML)is a highly aggressive hematological malignancy.Its complex pathological mechanisms and high recurrence rate pose significant challenges to clinical treatment.Curcumin,a polyphenolic compound derived from the natural plant Curcuma longa,has attracted widespread attention in AML treatment in recent years due to its multi-targeted and multi-mechanistic anticancer properties.This article systematically reviewed the research progress of curcumin and its derivatives in AML,focusing on elaborating their mechanisms of action,including inducing apoptosis,triggering pyroptosis,regulating autophagy,reversing multidrug resistance,inhibiting immune escape,mediating epigenetic regulation,and inducing ferroptosis.Meanwhile,it discussed the synergistic efficacy-enhancing effects of curcumin with traditional chemotherapeutic drugs and the application of its derivatives in improving therapeutic efficacy.Additionally,it analyzes the challenges for clinical translation based on the limitations of current research,emphasizing the necessity of drug combination for sensitization and toxicity reduction,as well as the conduction of large-scale clinical trials.This review aimed to provide a theoretical basis and reference for in-depth research and clinical application of curcumin-related anti-AML therapeutic strategies.关键词
急性髓系白血病/姜黄素/姜黄素及其衍生物/姜黄素联合/药理作用Key words
Acute myeloid leukemia/Curcumin/Curcumin and its derivatives/Curcumin combination/Pharmacological activities分类
医药卫生引用本文复制引用
伍振辉,吴敏,高姚,梁桢尧,吴欣平,周露,袁秋全,刘凡,曾英坚..姜黄素及其衍生物在急性髓系白血病治疗中的研究进展[J].药学研究,2026,45(5):542-551,10.基金项目
国家自然科学基金项目(No.82305159、82260914) （No.82305159、82260914）
江西省卫生健康委科技计划项目(No.202210758) （No.202210758）
