菌物学报2026，Vol.45Issue(6)：312-321,10.DOI:10.13346/j.mycosystema.250312
溶洞沉积物源烟曲霉ZNM2-3次级代谢产物
Secondary metabolites of Aspergillus fumigatus ZNM2-3 from karst cave sediment
摘要
Abstract
The secondary metabolites of Aspergillus fumigatus ZNM2-3 isolated from the sediment of Nali Karst Cave in Shangsi County,Fangchenggang,Guangxi were studied.The secondary metabolites were isolated and purified by normal phase silica gel column chromatography and high-performance liquid chromatography.The structures were identified by electrospray ionization mass spectrometry(ESI-MS),NMR and other methods.The cytotoxic activity and α-glucosidase inhibitory activity of the compounds were determined,and the active compounds were verified by molecular docking.In total,13 compounds were isolated from Aspergillus fumigatus ZNM2-3.Of which compound 6 had cytotoxic activity;compounds 8 and 12 had certain inhibitory effects on α-glucosidase,with IC50 values of 9.46 μmol/L and 10.17 μmol/L,respectively.Molecular docking results showed that both of these two compounds could bind α-glucosidase in the form of hydrogen bonds,thereby inhibiting the degradation of the substrate by the enzyme.关键词
烟曲霉/次级代谢产物/细胞毒活性/α-葡萄糖苷酶抑制剂活性/分子对接Key words
Aspergillus fumigatus/secondary metabolites/cytotoxic activity/α-glucosidase inhibitor activity/molecular docking引用本文复制引用
位彩霞,陆勇杰,田静源,程可鑫,王聪,王佩,孔凡栋,周丽曼..溶洞沉积物源烟曲霉ZNM2-3次级代谢产物[J].菌物学报,2026,45(6):312-321,10.基金项目
国家自然科学基金(82104034) （82104034）
广西自然科学基金(2021GXNSFBA220040) （2021GXNSFBA220040）
广西民族大学校级引进人才科研启动项目(2020KJQD09) （2020KJQD09）
广西民族大学相思湖青年创新团队(2021RSCXSHQN01) This work was supported by the National Natural Science Foundation of China(82104034),the Natural Science Foundation of Guangxi Zhuang Autonomous Region(2021GXNSFBA220040),the Scientific Research Fund of Guangxi Minzu University(2020KJQD09),and the Xiangsi Lake Youth Innovation Team of Guangxi Minzu University(2021RSCXSHQN01). （2021RSCXSHQN01）
