生物医学工程研究2026，Vol.45Issue(2)：127-132,6.DOI:10.19529/j.cnki.1672-6278.2026.02.08
基于压力反馈系统的气道狭窄数值模拟研究
Numerical simulation study on airway stenosis based on the pressure feedback system
摘要
Abstract
Addressing the critical limitation of traditional computational fluid dynamics(CFD)simulations in evaluating airway ste-nosis—specifically,the neglect of the alveolar pressure feedback mechanism.We developed a multi-scale numerical model based on dynamic alveolar pressure feedback.Utilizing a 0D-3D coupling strategy,the model integrated three-dimensional upper airway geome-try with lumped parameter models representing the peripheral lung units,successfully replicating the physiological feedback inherent in spontaneous breathing.The simulation results accurately captured core pathophysiological phenomena,including"pendelluft"(22.2 mL reflux per cycle)and the dynamic accumulation of intrinsic positive end-expiratory pressure(PEEPi,steady-state value:6.97 Pa),alongside a marked reduction in breathing efficiency.Furthermore,we mechanistically revealed that pressure imbalance,driven by regional heterogeneity in time constants,was the key factor deteriorating respiratory function.This research provides an innovative numerical simulation framework for the functional assessment of airway stenosis and personalized treatment planning.关键词
气道狭窄/数值模拟/压力反馈系统/多尺度耦合/计算流体动力学Key words
Airway stenosis/Numerical simulation/Pressure feedback system/Multi-scale coupling/Computational fluid dy-namic分类
医药卫生引用本文复制引用
马琛,孟家欢,倪忠,万华靖,陈宇,罗凤鸣..基于压力反馈系统的气道狭窄数值模拟研究[J].生物医学工程研究,2026,45(2):127-132,6.基金项目
国家自然科学基金项目(32271542). （32271542）
