实验动物与比较医学2026，Vol.46Issue(3)：357-366,10.DOI:10.12300/j.issn.1674-5817.2025.122
中西医病证结合的痔疮动物模型研究现状与评价
A Review and Evaluation of Integrated Disease and Syndrome Animal Models for Hemorrhoids in Traditional Chinese and Western Medicine
摘要
Abstract
Hemorrhoids are common anorectal diseases with complex pathogenesis,and there is still a lack of ideal experimental animal models for research on their prevention and treatment.In this paper,Chinese and English databases are searched with the keywords"hemorrhoids"and"animal model",and 36 relevant studies are finally included.The shortcomings of existing hemorrhoid animal models in integrating the clinical disease and syndrome characteristics of traditional Chinese and Western medicine are systematically analyzed,and the consistency of various models with clinical practice is evaluated.The studies are divided into four categories according to modeling methods:chemical modeling,physical modeling,biological modeling,and combined modeling.The clinical consistency of modeling is evaluated in combination with the diagnostic points of hemorrhoids in traditional Chinese and Western medicine.The results show that there are significant differences in the reproduction of clinical indicators by different modeling methods.According to clinical consistency,the models can be divided into three grades:high-consistency models are mainly based on combined modeling methods(such as induction by carrageenan combined with norepinephrine hydrochloride),which can more comprehensively simulate core pathological changes such as venous congestion and local inflammation;moderate-consistency models adopt single chemical or physical intervention(such as local inflammation induced by croton oil or vein ligation),which can only reproduce part of the pathological process;low-consistency models mostly adopt direct stimulation,with limited research value for pathological characteristics.Existing animal models have obvious advantages in replicating Western medical structural lesions of hemorrhoids,but they still have obvious defects in simulating the chronic disease course and stably reproducing the characteristics of traditional Chinese medicine syndromes,and a unified standard has not yet been formed for the traditional Chinese medicine evaluation system of models.In conclusion,it is still necessary to further explore the construction of high-quality integrated disease and syndrome animal models for hemorrhoids in traditional Chinese and Western medicine.Future research should integrate the theories of traditional Chinese and Western medicine,adopt multi-factor chronic modeling strategies,and establish a standardized comprehensive evaluation system covering macroscopic signs and microscopic indicators.This paper provides a reference for constructing standardized integrated disease and syndrome animal models of hemorrhoids that conform to the pathological changes of Western medicine and take into account the characteristics of traditional Chinese medicine syndromes,with the aim of providing more effective experimental tools for research on the pathogenesis of hemorrhoids and their integrated prevention and treatment with traditional Chinese and Western medicine.关键词
痔疮/动物造模/中西医结合/临床吻合度/评价Key words
Hemorrhoids/Animal modeling/Integrated traditional Chinese and Western medicine/Clinical consistency/Evaluation分类
医药卫生引用本文复制引用
卜瑜,候金婷,李媛媛,沙静涛,解晨露,王文刚,孙兴伟..中西医病证结合的痔疮动物模型研究现状与评价[J].实验动物与比较医学,2026,46(3):357-366,10.基金项目
陕西省重点研发计划项目"基于网络药理学与分子对接方法和体外实验探讨痔炎冲洗散治疗混合痔的作用机制"(2025SF-YBXM-119) （2025SF-YBXM-119）
2023年中央公共卫生发展项目"省级中医药循证能力建设中心" （）
西安市中医医院院级科研课题"湿痒洗剂治疗肛门瘙痒症的临床疗效及作用机制研究"(2024YJ21) （2024YJ21）
