外科理论与实践2026，Vol.31Issue(2)：100-107,8.DOI:10.16139/j.1007-9610.2026.02.02
HPV感染相关肛门癌的预防与筛查:现状、挑战与未来
Prevention and screening of HPV-associated anal cancer:current status,challenges,and future perspectives
摘要
Abstract
Anal cancer is a malignancy closely associated with human papillomavirus(HPV)infection,with a rising incidence globally.Persistent infection with high-risk HPV acted as the core driver of anal tumorigenesis.Currently,strategies for the prevention and control of HPV-related anal cancer primarily revolve around primary prevention(HPV vaccination)and secondary prevention(screening of high-risk populations).Based on existing evidence,HPV vaccination served as the core of primary prevention and demonstrated clear efficacy in reducing the incidence of anal intraepithelial neoplasia(AIN)by blocking persistent high-risk HPV infection.Regarding secondary prevention,domestic and international guidelines have reached a consensus recommending standardized screening based on anal cytology,high-risk HPV testing,and anoscopy for high-risk groups,such as people living with human immunodeficiency virus(HIV)and men who have sex with men(MSM),to facilitate early detection and intervention.关键词
人乳头瘤病毒疫苗/肛门癌/一级预防/筛查Key words
Human papillomavirus(HPV)vaccination/Anal cancer/Primary prevention/Screening分类
医药卫生引用本文复制引用
沈洁,居星语,郑莹..HPV感染相关肛门癌的预防与筛查:现状、挑战与未来[J].外科理论与实践,2026,31(2):100-107,8.基金项目
上海市公共卫生研究专项(2024GKM32) （2024GKM32）
上海市徐汇区院地合作项目(23XHYD-04) （23XHYD-04）
上海市2024年度"科技创新行动计划"科普专项(24DZ2300300) （24DZ2300300）
