外科理论与实践2026，Vol.31Issue(2)：108-113,6.DOI:10.16139/j.1007-9610.2026.02.03
结直肠癌化疗:基石地位巩固与精准化发展
Chemotherapy for colorectal cancer:consolidation of the cornerstone and advances in precision
摘要
Abstract
As the cornerstone of systemic treatment for colorectal cancer,chemotherapy(cytotoxic drug therapy)continues to evolve in clinical practice,with its scope and application significantly expanding.In the treatment of advanced disease,the combination of chemotherapy with targeted and immunotherapeutic agents has been continuously optimized,leading to the development of precision treatment strategies tailored to different molecular subtypes,which has markedly improved therapeutic efficacy.In the field of perioperative therapy,the application of neoadjuvant chemotherapy,total neoadjuvant therapy(TNT),and the precision enhancement of adjuvant chemotherapy are reshaping the treatment landscape for patients with resectable colorectal cancer.Furthermore,novel technologies such as circulating tumor DNA offer the potential for prediction and dynamic monitoring of clinical decision and chemotherapy efficacy.From the perspective of chemotherapy,this article systematically analyzed its role in the treatment system for colorectal cancer,and discussed its clinical challenges and future directions.关键词
结直肠癌/化疗/新辅助治疗/辅助治疗/姑息治疗Key words
Colorectal cancer/Chemotherapy/Neoadjuvant therapy/Adjuvant therapy/Palliative treatment分类
医药卫生引用本文复制引用
姚望,张俊..结直肠癌化疗:基石地位巩固与精准化发展[J].外科理论与实践,2026,31(2):108-113,6.基金项目
国家自然科学基金(82573607,82273126) （82573607,82273126）
