外科理论与实践2026，Vol.31Issue(2)：129-136,8.DOI:10.16139/j.1007-9610.2026.02.06
腹腔镜胃旁路术治疗肥胖合并多囊卵巢综合征疗效荟萃分析
Meta-analysis of the therapeutic effect of LRYGB in patients with obesity-related polycystic ovary syndrome
摘要
Abstract
Objective To systematically evaluate the therapeutic effect of laparoscopic Roux-en-Y gastric bypass(LRYGB)in patients with obesity comorbid with polycystic ovary syndrome(PCOS).Methods A systematic literature search was conducted across four databases(PubMed,Embase,Web of Science,and Scopus)for studies published up to January 1,2025.Following screening against predefined eligibility criteria,a total of 6 studies comprising 128 patients were ultimately included.Results Following LRYGB,there was a significant reduction in the number of patients with menstrual irregularities(OR=0.07;95％CI:0.04～0.14;P<0.05).Additionally,significant improvements were observed in hirsutism(OR=0.14;95％CI:0.06～0.32;P<0.05),sex hormone-binding globulin(SHBG)(MD=23.24;95％CI:7.97～38.51;P<0.05),free androgen index(FAI)(MD=-3.89;95％CI:-5.33～-2.45;P<0.05),total testosterone levels(MD=-25.55;95％CI:-30.08～-21.01;P<0.05),and body mass index(BMI)(MD=-17.22;95％CI:-19.32～-15.11;P<0.000 1).Conclusions LRYGB can serve as an effective therapeutic intervention to improve body weight and metabolic profiles in the population with obesity comorbid with PCOS.关键词
减重手术/腹腔镜Roux-en-Y胃旁路术/多囊卵巢综合征/肥胖症Key words
Bariatric surgery/Laparoscopic Roux-en-Y gastric bypass(LRYGB)/Polycystic ovary syndrome(PCOS)/Obesity分类
医药卫生引用本文复制引用
王书翰,任振,韦笑韩,刘虎,潘晨,吴立胜..腹腔镜胃旁路术治疗肥胖合并多囊卵巢综合征疗效荟萃分析[J].外科理论与实践,2026,31(2):129-136,8.基金项目
吴阶平医学基金会临床科研专项基金资助项目(320.6750.2022-07-7) （320.6750.2022-07-7）
