外科理论与实践2026，Vol.31Issue(2)：163-168,6.DOI:10.16139/j.1007-9610.2026.02.11
3-吲哚甲醇抗肿瘤作用的研究进展
Progress in the anti-tumor effects of indole-3-carbinol
摘要
Abstract
In recent years,indole-3-carbinol(I3C)has been introduced into tumor therapy research,playing a key role in inhibiting and interfering with the occurrence and development of various tumors.This article explored the mechanisms by which I3C and its indole-derived metabolite,3,3'-diindolylmethane(DIM),which is converted in the acidic environment of the stomach,serve as effective natural chemopreventive agents against multiple tumors.The physicochemical properties of I3C were presented alongside epidemiological studies,emphasizing its safety and efficacy.Furthermore,it provided a detail discussion of the molecular mechanisms of I3C's anti-tumor effects,including various signaling pathways such as the phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin[PI3K/PKB(AKT)/mTOR]and aryl hydrocarbon receptor(AHR)pathways.This article served as a valuable reference for further research on I3C.关键词
3-吲哚甲醇/磷脂酰肌醇3-激酶/蛋白激酶B通路/芳香烃受体/抗肿瘤Key words
Indole-3-carbinol(I3C)/Phosphoinositide 3-kinase/protein kinase B[PI3K/PKB(AKT)pathway]/Aryl hydrocarbon receptor(AHR)/Anti-tumor分类
医药卫生引用本文复制引用
王贵民,樊昊,周乐其,温镕博,于冠宇,郝立强,张卫..3-吲哚甲醇抗肿瘤作用的研究进展[J].外科理论与实践,2026,31(2):163-168,6.基金项目
国家自然科学基金(82072750) （82072750）
