外科理论与实践2026，Vol.31Issue(2)：169-174,6.DOI:10.16139/j.1007-9610.2026.02.12
多倍体肝细胞状态对肝纤维化、肝硬化以及肿瘤复发的影响
Impact of polyploid hepatocyte status on liver fibrosis,liver cirrhosis,and tumor recurrence
摘要
Abstract
Human somatic cells are inherently diploid,and an increase in chromosomal content results in polyploidy.The liver is one of the few human organs that is uniquely enriched in polyploid hepatocytes.Hepatocyte polyploidization participates in liver development and the progression of diverse hepatic diseases.This review systematically integrated recent advances in hepatocyte ploidy research by outlining the principal modes of ploidy transition,delineating distinct ploidy states,and emphasizing the mechanistic differences between binucleated and mononucleated polyploid hepatocytes.We further concentrated on mononucleated polyploid hepatocytes,examining the pathological conditions that underpin their emergence and linking these changes to liver cirrhosis and hepatocellular carcinoma(HCC)recurrence.Across chronic liver diseases that predispose to liver cirrhosis,aberrant expansion of mononucleated polyploid hepatocytes not only accelerated progression liver fibrosis and cirrhosis,but also showed a strong association with clinical outcomes in patients with HCC.Elucidating the regulatory mechanisms that govern mononucleated polyploidization will provide a conceptual foundation for improving the fibrotic and cirrhotic microenvironment and for informing therapeutic strategies aimed at preventing HCC recurrence.关键词
多倍体/肝细胞/倍性/肝纤维化/肝细胞癌Key words
Polyploidy/Hepatocyte/Ploidy/Liver fibrosis/Hepatocellular carcinoma分类
医药卫生引用本文复制引用
骆薪屹,鲁逸权,张亦凡,汪楠,郝风节,王俊青..多倍体肝细胞状态对肝纤维化、肝硬化以及肿瘤复发的影响[J].外科理论与实践,2026,31(2):169-174,6.基金项目
国家自然科学基金(82372603、82172900) （82372603、82172900）
希思科—朝阳肿瘤研究基金(Y-Young2021-0015) （Y-Young2021-0015）
上海市东方英才计划拔尖项目(BJJY2024068) （BJJY2024068）
