外科理论与实践2026，Vol.31Issue(2)：175-182,8.DOI:10.16139/j.1007-9610.2026.02.13
中药槐耳治疗消化系统恶性肿瘤的研究进展
Progress of traditional Chinese herbal medicine Vanderbylia robiniophila in the treatment of malignant tumors of digestive system
摘要
Abstract
Malignant tumors of the digestive system are associated with high morbidity and mortality rates,and their incidence has been increasing among younger populations in recent years.Although current comprehensive treatment strategies,which are primarily based on surgical resection and integrated with neoadjuvant chemoradiotherapy,postoperative chemoradiation,targeted therapy,and immunotherapy,have achieved substantial progress,the prognosis for certain patients remains poor due to drug resistance,advanced disease stages,or poor treatment tolerance.Vanderbylia robiniophila,a traditional Chinese herbal medicine,has been utilized as both a first-line and adjunctive therapeutic agent for digestive system malignancies,and has demonstrated notable antitumor efficacy.In recent years,multiple in vitro studies have elucidated several underlying antitumor mechanisms,including modulation of tumor cell stemness,induction of tumor cell death,and regulation of the tumor microenvironment.This review summarized the current understanding of the molecular mechanisms through which Vanderbylia robiniophila exerts its antitumor effects,highlighting its considerable therapeutic potential in digestive system malignancies.In addition,it provided a comprehensive overview of the therapeutic efficacy and corresponding molecular mechanisms of Vanderbylia robiniophila across various digestive system cancers,thereby providing theoretical support for its clinical application.Furthermore,this review proposes future research directions to further elucidate the antitumor properties of Vanderbylia robiniophila,aiming to inform and inspire novel strategies for the comprehensive treatment of digestive system malignancies.关键词
槐耳/消化系统恶性肿瘤/肿瘤干性/肿瘤细胞死亡/肿瘤微环境Key words
Vanderbylia robiniophila/Malignant tumor of digestive system/Tumor stemness/Tumor cell death/Tumor microenvironment(TME)分类
医药卫生引用本文复制引用
陆亭谚,赵浩然,石松畅,李宗耀,邵岩飞,陈敬贤,孙晶..中药槐耳治疗消化系统恶性肿瘤的研究进展[J].外科理论与实践,2026,31(2):175-182,8.基金项目
国家自然科学基金(82473031,82273344) （82473031,82273344）
大学生创新创业训练计划(19250101) （19250101）
