湖北科技学院学报（医学版）2026，Vol.40Issue(3)：196-201,207,7.DOI:10.16751/j.cnki.2095-4646.25120904
根皮苷、三叶苷与根皮素的体外稳定性研究
In Vitro Stability Studies of Phlorizin,Trilobatin,and Phloretin
摘要
Abstract
Objective To investigate the in vitro stability of phlorizin,trilobatin,and phloretin.Methods High performance liquid chromatography-tandem mass spectrometry(HPLC-MS/MS)was employed to evaluate the stability of phloridzin,trilobatin,and phloretin in buffer solutions of various pH values(1.4,4.0,6.86,and 7.86),simulated gastric and intestinal fluids,and rat gastric and intestinal con-tents.Results Phlorizin and trilobatin degraded rapidly in strong acidic conditions,with trilobatin degrading at a higher rate than phlorizin.In neutral environments,the degradation of both compounds slows down.Under weakly alkaline conditions,initial degradation was rapid,but subsequently levels off.In both artificial and rat gastrointestinal fluids,the degradation of phlorizin and trilobatin were accelerated and ac-companied by the generation of phloretin.However,phloretin itself degraded rapidly in gastric acid and intestinal fluid,possessing an ex-tremely short half-life.Conclusion Phlorizin and trilobatin possess poor stability in the gastrointestinal environment,where they are prone to hydrolysis into phloretin.Furthermore,since phloretin itself is highly unstable,this instability significantly compromises their bioavailability.关键词
根皮苷/三叶苷/根皮素/稳定性Key words
Phlorizin/Trilobatin/Phloretin/Stability分类
医药卫生引用本文复制引用
管志威,刘超,王凯迪,李芳,李雪,王静,李艳丽,秦玲香,莫启贵,张飞雪..根皮苷、三叶苷与根皮素的体外稳定性研究[J].湖北科技学院学报（医学版）,2026,40(3):196-201,207,7.基金项目
湖北科技学院横向项目(2024HX162) （2024HX162）
