同位素2026，Vol.39Issue(3)：231-238,8.DOI:10.7538/tws.2026.youxian.034
加速器生产68Ge的铌镓胶囊靶制备工艺
Fabrication Process of Niobium-Gallium Capsule Targets for Cyclotron Production of 68Ge
赵紫宇 1王春林 2秦愿生 2周佳骏 2温凯 2杜进 3马承伟 2李光 2段菲 2褚浩淼 2慎育博 2王晓明 2李超 2王成志2
作者信息
- 1. 中国原子能科学研究院,北京 102413||原子高科股份有限公司,北京 102413||国家原子能机构 核技术(放射性药物工程转化)研发中心,北京 102413||中国核工业集团有限公司 放射性药物工程技术研究中心,北京 102413
- 2. 原子高科股份有限公司,北京 102413||国家原子能机构 核技术(放射性药物工程转化)研发中心,北京 102413||中国核工业集团有限公司 放射性药物工程技术研究中心,北京 102413
- 3. 中国原子能科学研究院,北京 102413||国家原子能机构 核技术(放射性药物工程转化)研发中心,北京 102413||中国核工业集团有限公司 放射性药物工程技术研究中心,北京 102413||中国同辐股份有限公司,北京 100089
- 折叠
摘要
Abstract
68Ge serves as the pivotal parent nuclide for the medical positron emitter 68Ga,rendering target design and fabrication critical for cyclotron-based production.This study systematically investigates the preparation of sealed Niobium-gallium capsule targets.Firstly,yield simulations using the FLUKA were conducted to the target design.Gradient experiments on gallium cavity depth and filling ratio were performed to determine the optimal target parameters and electron beam welding safe distance.The effect of gallium filling on welding performance was investigated through weld penetration analysis and X-ray diffraction.Subsequently,quality control was implemented through computed tomography imaging,helium mass spectrometry leak testing,and thermal shock experiments to ascertain high-temperature failure reason.Finally,hot experiments verified reliability of targets.The results indicate that excessive gallium will increase weld penetration and form the Ga5Nb4 compound,resulting in fracture failure of the target component.The optimal target structure is achieved at a gallium cavity depth of 1.35 mm and a filling ratio of 68%-72%.The target exhibits excellent hermeticity(leak rate<5×10-3 Pa·cm3/s)and thermal stability below 400℃.Hot experiments yielded approximately 2.7-3.9 GBq of 68Ge with radiochemical purity higher than 99.9%and element impurities below 2 ppm.This study demonstrates superior performance of niobium-gallium capsule targets fabricated via electron beam welding,providing critical process support for the scalable and safe production of 68Ge.关键词
68Ge/铌镓胶囊靶/真空电子束焊接Key words
68Ge/niobium-gallium capsule target/vacuum electron beam welding分类
能源科技引用本文复制引用
赵紫宇,王春林,秦愿生,周佳骏,温凯,杜进,马承伟,李光,段菲,褚浩淼,慎育博,王晓明,李超,王成志..加速器生产68Ge的铌镓胶囊靶制备工艺[J].同位素,2026,39(3):231-238,8.
