畜牧与兽医2026，Vol.58Issue(7)：123-129,7.
反向遗传学在细小病毒致病机制研究中的应用
Application of reverse genetic in studying the pathogenic mechanism of parvovirus
摘要
Abstract
Parvoviruses are single-stranded DNA(ssDNA)viruses that infect a wide range of hosts,including both invertebrates and ver-tebrates,posing a major threat to sustainable livestock production and public health security.Their pathogenicity involves direct damage to host cells,dysregulation of immune responses,and disruption of cell cycle control.Reverse genetics systems,through the construction of in-fectious clones and the application of gene editing tools,have provided key methodologies for elucidating the pathogenic mechanisms of parvo-viruses.This review summarizes the application of reverse genetics in studying the functions of parvoviral proteins and nucleic acids,with a focus on its role in uncovering viral pathogenesis.The aim is to offer theoretical insights for further understanding the pathogenic mechanisms of parvoviruses and for developing novel antiviral strategies and vaccines.关键词
细小病毒/反向遗传学/致病机制/结构蛋白/非结构蛋白Key words
parvovirus/reverse genetics/pathogenic mechanism/structural proteins/non-structural proteins分类
农业科技引用本文复制引用
姚梦凡,卢秦月,崔常勇,王建科..反向遗传学在细小病毒致病机制研究中的应用[J].畜牧与兽医,2026,58(7):123-129,7.基金项目
国家自然科学基金面上项目(32373001) （32373001）
河北农业大学引进人才科研专项(YJ2021019) （YJ2021019）
