疑难病杂志2026，Vol.25Issue(6)：682-687,6.DOI:10.3969/j.issn.1671-6450.2026.06.008
血清糖蛋白炎性标志物与肝硬化患者病情及预后的关系分析
Analysis of the relationship between glycoprotein inflammatory biomarkers in serum and the disease progression and prognosis of patients with liver cirrhosis
摘要
Abstract
Objective To investigate the relationship between serum scavenger receptor cysteine-rich family member with 5 domains(SSc5D),thrombospondin-1(THBS1)and the condition and prognosis of patients with liver cirrhosis.Meth-ods A total of 135 patients with liver cirrhosis admitted to the Department of Gastroenterology,the Third People's Hospital of Xinjiang Uygur Autonomous Region from January 2023 to January 2025 were selected as the liver cirrhosis group.Accord-ing to disease severity,patients with liver cirrhosis were divided into a mild subgroup(51 cases),a moderate subgroup(47 ca-ses),and a severe subgroup(37 cases).Based on prognosis after 6 months of follow-up,patients were divided into a poor prognosis subgroup and a good prognosis subgroup.In addition,135 healthy subjects were selected as the healthy control group at a 1∶1 ratio.Enzyme-linked immunosorbent assay was used to detect serum SSc5D and THBS1 levels.Spearman cor-relation analysis was used to analyze the correlation between serum SSc5D and THBS1 levels and disease severity.Factors in-fluencing poor prognosis and the predictive efficacy of serum SSc5D and THBS1 levels were analyzed.Results Compared with the healthy control group,serum SSc5D and THBS1 levels were significantly higher in the liver cirrhosis group(t=14.047,13.002,both P＜0.001).Serum SSc5D and THBS1 levels progressively increased across the mild,moderate,and severe subgroups(F=112.695,66.999,both P＜0.001).Serum SSc5D and THBS1 levels were positively correlated with disease sever-ity(rs=0.678,0.551,both P＜0.001).After 6 months of follow-up,the poor prognosis rate among the 135 patients with liver cirrhosis was 30.37％(41/135).Compared with the good prognosis subgroup,the poor prognosis subgroup had more severe disease,higher model for end-stage liver disease(MELD)scores,and higher levels of SSc5D and THBS1(x2/t=-6.272,3.934,6.814,7.296,all P＜0.001).Severe cirrhosis,high MELD score,elevated SSc5D,and elevated THBS1 were independent risk factors for poor prognosis in patients with cirrhosis[OR(95％CI)=7.553(1.442-39.554),1.252(1.094-1.433),1.366(1.152-1.618),2.670(1.708-4.174)].The AUCs of serum SSc5D,THBS1,and their combination in predicting poor prognosis were 0.804,0.826,and 0.905,respectively.The combination was superior to the individual predictive efficacy of ser-um SSc5D and THBS1(Z=3.140,2.410;P=0.002,0.016).Conclusion Elevated serum SSc5D and THBS1 levels are asso-ciated with disease progression in patients with cirrhosis,and both are independent risk factors for poor prognosis.The combi-nation of serum SSc5D and THBS1 levels has higher predictive efficacy for prognosis.关键词
肝硬化/具有5个结构域的富半胱氨酸清道夫受体家族成员/血小板反应蛋白1/病情/预后Key words
Liver cirrhosis/Scavenger receptor cysteine-rich family member with 5 domains/Thrombospondin-1/Disease severity/Prognosis分类
医药卫生引用本文复制引用
肖勇,曹璐,宋涛,孙燕辉..血清糖蛋白炎性标志物与肝硬化患者病情及预后的关系分析[J].疑难病杂志,2026,25(6):682-687,6.基金项目
新疆维吾尔自治区卫生健康医学科研项目(WJWY-2022018) （WJWY-2022018）
新疆维吾尔自治区第三人民医院项目(2024QSYYK09) Xinjiang Uygur Autonomous Region Health Medicine Research Project(WJWY-2022018) （2024QSYYK09）
Third People's Hospital of Xinjiang Uygur Autonomous Region Project(2024QSYYK09) （2024QSYYK09）
