疑难病杂志2026，Vol.25Issue(6)：747-751,755,6.DOI:10.3969/j.issn.1671-6450.2026.06.021
幽门螺杆菌不同根除治疗方案及影响因素研究进展
Research progress on different eradication treatment regimens for Helicobacter pylori and their influencing factors
摘要
Abstract
Helicobacter pylori(Hp)is a Gram-negative,transmissible pathogen responsible for human gastric diseases,with approximately half of the global population infected.Eradication of Hp has been proven to effectively reduce the risk of gastric cancer.In China,however,the limitations of current therapeutic regimens and multiple factors influencing treat-ment outcomes have rendered Hp eradication substantially challenging.This review systematically summarizes the progress of first-line therapy,second-line rescue therapy and non-antibiotic alternative strategies for Hp eradication,and discusses key de-terminants of treatment efficacy,including antibiotic resistance,CYP2C19 gene polymorphisms,and patient compliance,with the aim of providing clinical references for optimizing Hp eradication strategies.关键词
幽门螺杆菌/根除治疗/影响因素Key words
Helicobacter pylori/Eradication therapy/Influencing factors分类
医药卫生引用本文复制引用
谢文丽,杨杰,武胜..幽门螺杆菌不同根除治疗方案及影响因素研究进展[J].疑难病杂志,2026,25(6):747-751,755,6.基金项目
贵阳市科技计划项目(筑科合同[2018]1-85号) Guiyang Science and Technology Program Project(Zhuke Contract[2018]1-85) （筑科合同[2018]1-85号）
