疑难病杂志2026，Vol.25Issue(6)：756-762,768,8.DOI:10.3969/j.issn.1671-6450.2026.06.023
炎性反应-代谢标志物在糖尿病肾病进展中的研究现状
Research status of inflammatory metabolic markers in the progress of diabetic nephropathy
摘要
Abstract
diabetic nephropathy(DN)is the most common microvascular complication of diabetic and the primary cause of end stage renal disease(ESRD),which seriously threatens the quality of life of patients.The interaction and crosstalk between metabolic disorders and chronic inflammation are the core pathological mechanisms driving the progression of diabetic nephropathy,forming a vicious cycle of"metabolic abnormalities inflammation amplification renal injury aggrava-tion",and participating in key pathological processes such as glomerulosclerosis and tubulointerstitial fibrosis.Inflammation metabolic markers can simultaneously reflect the metabolic imbalance and inflammatory activation status of the body,covering multiple categories such as classical inflammatory factors,inflammasomes,acute phase response proteins,glucose and lipid metabolites,oxidative stress,and adipokines.They can compensate for the lack of sensitivity and specificity of a single marker and have important value in early warning,disease stratification,prognosis evaluation,and efficacy monitoring of diabetic ne-phropathy.Therefore,elucidating the mechanism of action,detection value,and clinical application of inflammation metabolic markers in the system can provide important basis for early diagnosis,precise intervention,and development of new targets for DN.This article reviews the classification of inflammation metabolic markers,their mechanisms of action in the progression of diabetic nephropathy,their clinical application value,and research prospects.关键词
糖尿病肾病/炎性反应/代谢/生物标志物/疾病进展Key words
Diabetic nephropathy/Inflammation/Metabolism/Biomarkers/Disease progression分类
医药卫生引用本文复制引用
黄辛欣,李智明,蒙绪标..炎性反应-代谢标志物在糖尿病肾病进展中的研究现状[J].疑难病杂志,2026,25(6):756-762,768,8.基金项目
2022年海南省自然科学基金立项项目(822MS201) 2022 Hainan Provincial Natural Science Foundation Project(822MS201) （822MS201）
