右江医学2026，Vol.54Issue(5)：417-422,6.DOI:10.3969/j.issn.1003-1383.2026.05.001
心率-血压双靶点管理对射血分数下降型心力衰竭预后的影响:机制、证据与临床实践
Impact of dual-target management of heart rate and blood pressure on the prognosis of heart failure with reduced ejection fraction:mechanism,evidence,and clinical practice
摘要
Abstract
Heart rate and blood pressure are established therapeutic targets for prognostic improvement in heart failure with reduced ejection fraction(HFrEF);however,the mechanisms and strategies for their synergistic management remain to be fully eluci-dated.This review synthesizes evidence from the past 10 years,integrates pathophysiological mechanism studies,randomized controlled trials(RCTs),and real-world data from databases such as PubMed and CNKI,and focuses on the impact of dual target management on the prognosis of HFrEF.Research has confirmed that resting heart rate＞70 beats/min or systolic blood pressure(SBP)＜110 mmHg(or＞140 mmHg)in HFrEF patients significantly increases the risk of mortality.Dynamic monitoring combined with biomarkers can optimize treatment goals,and early use of beta blockers and ivabradine can accelerate heart rate to reach the target.In conclusion,breaking through the"one-size-fits-all"management model and establishing individualized strategies based on hemodynamics and molecular biomarkers are the key directions for improving the prognosis of HFrEF patients in the future.关键词
射血分数下降型心衰/心率/血压Key words
heart failure with reduced ejection fraction(HFrEF)/heart rate/blood pressure分类
医药卫生引用本文复制引用
谭玉燕,冉玉柳,刘燕..心率-血压双靶点管理对射血分数下降型心力衰竭预后的影响:机制、证据与临床实践[J].右江医学,2026,54(5):417-422,6.基金项目
广西自然科学基金(2024JJH140107) （2024JJH140107）
