右江医学2026，Vol.54Issue(5)：430-438,9.DOI:10.3969/j.issn.1003-1383.2026.05.003
孕期增重与妊娠期高血压疾病的关联及阈值效应分析
Association between gestational weight gain and hypertensive disorders of pregnancy:an analysis of threshold effects
摘要
Abstract
Objective To explore association between gestational weight gain(GWG)and the risk of hypertensive disor-ders of pregnancy(HDP).Methods Delivery and antenatal examination records of 58 564 parturient women in Nanning City were retrospectively collected from the Gui Maternal and Child Health Service Information Management System.Multiva-riate logistic regression and threshold effect analysis were used to assess the associations between GWG,gestational weight gain patterns,and the risk of HDP.Additionally,restricted cubic splines were applied to fit the dose-response relationship between GWG and HDP.Results A total of 3345 women(5.71％)were diagnosed with HDP.After adjusting for covari-ates,each 1 kg increase in GWG was associated with a significant 4％increase in risk of HDP(OR=1.04,P＜0.001).A U-shaped dose-response relationship was observed between GWG and HDP risk,with the inflection point of the threshold effect at 11.29 kg.When GWG＜11.29 kg,there was a significant negative association between GWG and HDP risk(OR=0.96,P=0.003).Subgroup analysis showed that,except for the significantly reduced HDP risk with increasing GWG in women aged＜35 years,those with hemoglobin levels ≥110 g/L during pregnancy,those without gestational diabetes,and urban women,there were no significant associations in the remaining subgroups.When GWG≥11.29 kg,GWG was signifi-cantly positively associated with HDP risk(OR=1.08,P＜0.001),and this effect was consistent across all subgroups with-out significant effect modification.Compared with the pattern of sustained moderate weight gain during pregnancy,pregnant women with the patterns of sustained low weight gain during pregnancy,accelerated weight gain in the second and third trimesters,and rapid and high weight gain in the second and third trimesters had a 25％(OR=1.25,P＜0.001),22％(OR=1.22,P＜0.001),and 82％(OR=1.82,P＜0.001)increased risks of HDP,respectively.Conclusion There is a U-shaped relationship between GWG and HDP risk,both excessive and insufficient GWG are associated with an increased risk of HDP.关键词
孕期增重/妊娠期高血压疾病/阈值效应/母婴结局Key words
weight gain during pregnancy/hypertensive disorders of pregnancy/threshold effect/maternal and neonatal perinatal outcomes分类
医药卫生引用本文复制引用
黄冬梅,韦明晓,刘顺,杨兴,毛良勤,王晓敏..孕期增重与妊娠期高血压疾病的关联及阈值效应分析[J].右江医学,2026,54(5):430-438,9.基金项目
国家自然科学基金(82160623) （82160623）
