中国癌症杂志2026，Vol.36Issue(5)：496-500,5.DOI:10.19401/j.cnki.1007-3639.2026.05.008
磷酸肌酸代谢在肿瘤研究中的新进展
Recent advances in phosphocreatine metabolism and its role in cancer research
摘要
Abstract
Phosphocreatine(PCr),traditionally recognized as an intracellular high-energy phosphate compound,mainly functions as a rapid energy buffer through the creatine kinase system to meet the high-energy demands of cells.However,recent studies have revealed that the role of PCr extends beyond this conventional view;it plays multiple roles in tumor metabolism,especially in maintaining tumor stem cell stemness,regulating epigenetics,remodeling metabolism,and contributing to drug resistance.PCr not only supports the energy supply required for the rapid proliferation of tumor cells but also affects processes such as chromosome segregation and cell cycle regulation by modulating the stability of key proteins.Moreover,PCr metabolism can serve as a therapeutic target,where inhibiting its synthesis pathway significantly suppresses tumor growth and exhibits synergistic effects with existing epigenetic inhibitors,providing new strategies for cancer therapy.This review focuses on the latest advancements including the regulation of tumor cell proliferation,migration,and invasion by PCr,its core role in maintaining tumor stemness and epigenetic remodeling,its involvement in the molecular pathways of tumor drug resistance,and new strategies for anti-tumor therapy targeting PCr metabolism.This review systematically summarizes the recent progress in PCr metabolism in tumorigenesis,tumor progression,and treatment,analyzes its multifaceted functions in tumor cell biology,and explores its potential application value in targeted therapy.关键词
磷酸肌酸/肌酸激酶/肿瘤代谢/肿瘤干细胞/耐药性/靶向治疗Key words
Phosphocreatine/Creatine kinase/Tumor metabolism/Tumor stem cells/Drug resistance/Targeted therapy分类
医药卫生引用本文复制引用
董皓轩,赵梦洁,刘亮,钱春发..磷酸肌酸代谢在肿瘤研究中的新进展[J].中国癌症杂志,2026,36(5):496-500,5.基金项目
国家自然科学基金(82403956,82203637). National Natural Science Foundation of China(82403956,82203637). （82403956,82203637）
