中草药2026，Vol.57Issue(12)：4876-4888,13.DOI:10.7501/j.issn.0253-2670.2026.12.029
酒制对中药寒热药性的定向调控及增效减毒机制研究进展
Research progress on directional regulation of cold and hot medicinal properties,efficacy enhancement and detoxification mechanisms of traditional Chinese medicine by wine-processing
摘要
Abstract
As a classic method of traditional Chinese medicine(TCM)processing,wine-processing has been employed for toxin reduction and preservation of medicinal properties,efficacy enhancement and medicinal property modification,or purposely guiding the therapeutic effects of herbal medicines.This review retrieved literature from PubMed,Web of Science,China national knowledge infrastructure(CNKI),and Wanfang databases using keywords including"wine-processing""medicinal properties"and"efficacy-enhancing mechanisms".Findings indicate that traditional wine-processing predominantly utilizes HuangJiu,with distinctive techniques such as wine rinsing,wine stir-frying and wine steaming remaining in current practice.Modern processing technology emphasizes optimization of critical parameters.Wine-processing facilitates component transformation through physical dissolution,enhanced cellular permeability,and synergistic enzymatic/non-enzymatic reactions.Mechanisms involving multi-target networks and microbiota-targeted metabolic regulation,enable directional modulation of herbal cold/hot properties alongside efficacy enhancement and toxicity reduction.Future research should prioritize establishing digitalized process quality control standards,conduct interdisciplinary investigations into wine-processing effects on efficacy-related component groups,and elucidate directional regulation mechanisms of medicinal properties.These advancements are anticipated to promote standardization and modernization of wine-processing techniques while scientifically interpreting the theoretical foundations of TCM processing.关键词
中药炮制/酒制/药性/工艺优化/增效机制/成分转化Key words
traditional Chinese medicine processing/wine-processing/medicinal properties/process optimization/efficacy-enhancing mechanisms/component transformation分类
医药卫生引用本文复制引用
高晴琪,郑灵玲,郭彤,叶琪涛,王依雯,童超英,邹莉,寿旦..酒制对中药寒热药性的定向调控及增效减毒机制研究进展[J].中草药,2026,57(12):4876-4888,13.基金项目
国家自然科学基金资助项目(82474144) （82474144）
浙江省万人计划科技创新领军人才项目(2022R52031) （2022R52031）
浙江中医药大学科研资助项目(2025JKZDZC04) （2025JKZDZC04）
