中草药2026，Vol.57Issue(12)：4889-4900,12.DOI:10.7501/j.issn.0253-2670.2026.12.030
心肌梗死后心肌纤维化的病理机制及其中医药防治研究
Myocardial fibrosis after myocardial infarction:Pathological mechanisms and therapeutic potential of traditional Chinese medicine
摘要
Abstract
Myocardial fibrosis(MF)is a key pathological feature following myocardial infarction(MI).This condition leads to myocardial stiffening and impaired cardiac pumping,ultimately resulting in complications including arrhythmias,heart failure,and cardiac rupture.Currently,interventions such as chemical drugs and surgery play an important role in the treatment of post-MI MF.However,they are still limited by suboptimal prognoses and high medical costs.Meanwhile,traditional Chinese medicine(TCM)has demonstrated potential value in this area,owing to its holistic regulation and multi-target therapeutic effects.This review provides a systematic overview of the pathological mechanisms underlying MF after MI and the preventive and therapeutic strategies of TCM for this disease.It aims to provide references for future clinical research and guide drug development efforts.关键词
心肌纤维化/心肌梗死/信号通路/中医药/作用机制Key words
myocardial fibrosis/myocardial infarction/signal pathway/traditional Chinese medicine/mechanism of action分类
医药卫生引用本文复制引用
靳雅惠,刘星雨,折煜轩,陈语涵,刘博,张博,高枫,陆晨曦..心肌梗死后心肌纤维化的病理机制及其中医药防治研究[J].中草药,2026,57(12):4889-4900,12.基金项目
国家自然科学基金资助项目(82460765) （82460765）
陕西省教育厅一般项目(24JK0730,25JK0747) （24JK0730,25JK0747）
陕西省秦创原"科学家+工程师"队伍建设项目(2025QCY-KXJ-185) （2025QCY-KXJ-185）
陕西省自然科学基础研究计划项目(2025JC-YBMS-1027) （2025JC-YBMS-1027）
延安大学博士科研启动项目(YDBK2023-75) （YDBK2023-75）
国家级大学生创新创业计划训练项目(202410719011) （202410719011）
