针刺研究2026，Vol.51Issue(6)：796-802,7.DOI:10.13702/j.1000-0607.20250690
针灸多靶点协同调控慢性阻塞性肺疾病免疫炎性稳态的研究进展
Research progress on acupuncture in multi-target synergistic regulation of immune-inflammatory homeostasis in chronic obstructive pulmonary disease
摘要
Abstract
The pathological development of chronic obstructive pulmonary disease(COPD)is closely related to the imbalance of immune-inflammatory homeostasis,mainly involving the dysregulation of T helper(Th)cell subset homeostasis,imbalance of inflammatory cell networks,cytokine storm,regulation of inflammatory signaling pathways,activation of the cholinergic anti-inflammatory pathway,autophagy-mediated inflammatory response,and regulation of other inflammatory pathways.Through the multidimensional regulatory network of"acupoint-nerve-immunity",acupuncture can simultaneously act on multiple key nodes such as the cholinergic anti-inflammatory pathway,kinase-mediated inflammatory response pathways,to remodel Th17/regulatory T lymphocyte(Treg)balance,and regulation of macrophage classical activation(M1)/alternative activation(M2)polarization,demonstrating superior homeostasis-regulating characteristics.This article systematically reviews the latest research progress on acupuncture in the multi-target synergistic regulation of immune-inflammatory homeostasis in COPD,aiming to provide evidence for the integrated treatment of COPD.关键词
慢性阻塞性肺疾病/针灸/多靶点/免疫调节/炎性反应/研究进展Key words
Chronic obstructive pulmonary disease/Acupuncture/Multi-target/Immunoregulation/Inflammatory response/Research progress引用本文复制引用
王嘉轩,尚小龙,夏红燕,易正珩,郭俊成..针灸多靶点协同调控慢性阻塞性肺疾病免疫炎性稳态的研究进展[J].针刺研究,2026,51(6):796-802,7.基金项目
广东省中医药局科研项目(No.20231234) （No.20231234）
