中国免疫学杂志2026，Vol.42Issue(6)：1475-1481,7.DOI:10.3969/j.issn.1000-484X.2026.06.031
铁死亡与炎症信号通路:机制与联系
Ferroptosis and inflammatory signaling pathways:Mechanisms and associations
摘要
Abstract
Ferroptosis is a new type of programmed cell death induced by Fe2+overload,abnormal amino acid metabolism and lipid peroxide accumulation.Inflammation is the body's defense mechanism against infection,injury or other irritation.Inflammatory response can activate a variety of inflammation-related signaling pathways and jointly promote the occurrence of ferroptosis by regulat-ing iron metabolism,ROS production,antioxidant defense,lipid metabolism and mitochondrial function.Among the relevant signal transduction pathways,this paper focuses on five classical inflammatory pathways,namely,JAX-STAT,NF-κB,inflammasome,c GAS-STING and MAPK and elaborates their roles in ferroptosis,which is helpful to further understand the pathophysical process of iron death.Study of these inflammatory pathways provides new thinking and research directions for further exploring the mechanism of ferroptosis and provides appropriate therapeutic approaches for the intervention of ferroptosis-related diseases.关键词
铁死亡/细胞凋亡/病理机制/炎症反应/氧化应激Key words
Ferroptosis/Apoptosis/Pathological mechanism/Inflammatory response/Oxidative stress分类
医药卫生引用本文复制引用
郭世娇,张晨淼,张银花,童津津..铁死亡与炎症信号通路:机制与联系[J].中国免疫学杂志,2026,42(6):1475-1481,7.基金项目
国家自然科学基金项目(322272904). （322272904）
