中国免疫学杂志2026，Vol.42Issue(6)：1522-1529,8.DOI:10.3969/j.issn.1000-484X.2026.06.038
巨噬细胞极化在慢性难愈性创面发病机制中的研究进展
Research progress on macrophage polarization in pathogenesis of chronic refractory wounds
摘要
Abstract
Chronic refractory wounds(CRW)are mainly characterized by sustained wound inflammation.With complicated pathogenesis and poor therapeutic outcomes,they severely impair patients'physical and psychological well-being.The dysregulation of macrophage polarization plays a crucial role in perpetuating the inflammatory process in CRW,hindering wound healing.By modu-lating macrophage polarization,it is possible to regulate inflammation levels,enhance angiogenesis and granulation tissue formation,and expedite wound healing,making it a focal point in repair CRW research.Multiple pathways,such as nucleotide-binding oligomer-ization domain-like receptor protein 3/caspase-1(NLRP3/caspase-1),neurogenic locus notch homolog protein 1/immunoglobulin Jκ region reambination signal sequence-binding protein(Notch1/RBP-Jκ),Toll-like receptor 4(TLR4),nuclear factor E2-related factor 2/heme oxygenase-1(Nrf2/HO-1),and adenylate-activated protein kinase(AMPK),are implicated in the regulation of macrophage polarization.However,further investigation is required to elucidate the specific regulatory mechanisms.Therefore,from the perspec-tive of macrophage polarization,this review summarizes its role in wound healing,key factors influencing chronic refractory wound re-pair,and related molecular mechanisms,so as to provide new therapeutic strategies and directions for CRW.关键词
巨噬细胞/极化/慢性难愈合创面/发病机制/研究进展Key words
Macrophage/Polarization/Chronic refractory wounds/Pathogenesis/Research progress分类
医药卫生引用本文复制引用
杨柳,丁雅容,贺梅津,余佳林,廖亮英,黄新宇,周忠志..巨噬细胞极化在慢性难愈性创面发病机制中的研究进展[J].中国免疫学杂志,2026,42(6):1522-1529,8.基金项目
湖南省临床医疗技术创新引导项目(2021SK51401). （2021SK51401）
