中国临床药理学杂志2026，Vol.42Issue(10)：1403-1408,6.DOI:10.13699/j.cnki.1001-6821.2026.10.009
度洛西汀在抑郁患者中的群体药代动力学研究
Population pharmacokinetics of duloxetine in patients with depression
摘要
Abstract
Objective To establish a population pharmacokinetic(PPK)model of duloxetine(DLXT)in hospitalized patients with depression,to investigate its influencing factors,and to provide reference for individualized medication.Methods A total of 325 patients who were hospitalized and received oral DLXT treatment at Shenzhen Kangning Hospital from January 2022 to October 2025 were retrospectively included,and their medication information,plasma concentrations,and other clinically relevant data were collected.Nonlinear mixed-effects modeling(NONMEM)was used to establish a PPK model of DLXT concentrations.Goodness-of-fit(GOF)plots,visual predictive check(VPC)and Bootstrap were used to evaluate the stability and predictive performance of the model,respectively.Based on the significant covariates identified in the final model,the steady-state plasma concentrations(Css)of DLXT over time were simulated under different dosage regimens in various populations.Results A one-compartment model with first-order absorption and elimination was developed using 450 plasma concentration data points from 325 inpatients.The inter-individual variability of apparent clearance(CL/F)was 42.2％,and the proportional residual variability was 27.1％.Gender was identified as a significant covariate affecting CL/F.The final model was expressed as:CL/F(L·h-1)=64.6 ×(1-0.25 × Gender),where Gender is an indicator variable(male=0,female=1).The apparent volume of distribution was 1 530 L,and the absorption rate constant was fixed at 0.168 h-1.Monte Carlo simulations showed that the Css in females was higher than that in males at the same doses.Conclusion A PPK model for DLXT in hospitalized patients with depression was successfully established.The final model is stable and reliable,and it can be used for individualized dosing regimens in clinical practice.关键词
度洛西汀/群体药代动力学/非线性混合效应模型/蒙特卡洛模拟Key words
duloxetine/population pharmacokinetics/nonlinear mixed-effects modeling/monte carlo simulation分类
医药卫生引用本文复制引用
钟易霖,曾环思,钟彩妮,曾位位..度洛西汀在抑郁患者中的群体药代动力学研究[J].中国临床药理学杂志,2026,42(10):1403-1408,6.基金项目
广东省高水平临床重点专科(深圳市配套建设经费)资助项目(SZGSP013) （深圳市配套建设经费）
深圳市康宁医院院内课题项目(KN2023B017) （KN2023B017）
