中国临床药理学杂志2026，Vol.42Issue(10)：1424-1432,9.DOI:10.13699/j.cnki.1001-6821.2026.10.012
脂滴-溶酶体轴在阿尔茨海默病中的作用机制及中药调控进展
Mechanisms of the lipid droplet-lysosome axis in Alzheimer's disease and advances in regulation by traditional Chinese medicine
摘要
Abstract
Alzheimer's disease(AD)is a multifactorial neurodegenerative disorder whose pathological process involves interactions among lipid metabolism disorders,abnormal protein aggregation,and organelle dysfunction.Recent studies have revealed that lipid droplets and lysosomes do not function independently;instead,they form a functional coupling via the lipophagy pathway,which is defined in this paper as the"lipid droplet lysosome axis".This axis centers on lipid droplet surface proteins(PLIN2,DGAT2,Rab7)and lysosomal functional molecules(v-ATPase,LAMP2 A,cathepsins),achieving bidirectional regulation through membrane contact sites,material exchange,and the mTORC1-TFEB signaling feedback loop.Under AD pathology,dysregulation of this axis manifests as a vicious cycle in which abnormal lipid droplet accumulation and lysosomal dysfunction mutually exacerbate each other,thereby promoting Aβ deposition and tau phosphorylation.This review systematically elaborates the biological basis and dysregulation mechanisms of this axis,and based on this framework,constructs an"axis node-TCM component"mechanistic mapping.It summarizes evidence that active ingredients from traditional Chinese medicine,such as ginsenosides,restore axis function via nodes including TFEB,AMPK,and PPARα,and proposes research strategies and validation pathways for targeting this axis as a novel multi-target therapeutic approach for AD.关键词
阿尔茨海默病/脂滴/溶酶体/研究进展/中医药Key words
Alzheimer's disease/lipid droplets/lysosomes/research progress/traditional Chinese medicine分类
医药卫生引用本文复制引用
黄嘉璇,关子赫,孙敏,江雨欣,付佳琪,付英婷,张明霞,常惟智..脂滴-溶酶体轴在阿尔茨海默病中的作用机制及中药调控进展[J].中国临床药理学杂志,2026,42(10):1424-1432,9.基金项目
黑龙江省中医药科研项目(ZYW2024-019) （ZYW2024-019）
