中国现代医学杂志2026，Vol.36Issue(11)：56-62,7.DOI:10.3969/j.issn.1005-8982.2026.11.008
tRFs在足细胞损伤与凋亡机制中的研究进展:以阿霉素肾病为模型的新视角
Research progress on tRFs in the mechanisms of podocyte injury and apoptosis:new insights from the adriamycin nephropathy model
摘要
Abstract
Chronic kidney disease(CKD)represents a major public health challenge,and its core pathological feature is podocyte injury.As terminally differentiated cells,podocytes are difficult to regenerate,making them a critical target for CKD prevention and treatment.The adriamycin-induced nephropathy(AN)model specifically induces podocyte injury,effectively mimicking key characteristics of human CKD,including proteinuria and glomerulosclerosis.Recent studies have identified transfer RNA-derived fragments(tRFs)as a novel class of non-coding RNAs that play important regulatory roles in podocyte injury.This review summarizes the mechanisms by which specific tRFs,such as tRF-003634,tRF-013354 and tRF-011690,mediate podocyte inflammation,apoptosis,and cytoskeletal remodeling through the modulation of signaling pathways including TLR4/NF-κB and Wnt/β-catenin.These findings reveal new functions of tRFs,provide insights into the pathogenesis of CKD,and highlight both the value and the challenges of their application as biomarkers and therapeutic targets.关键词
阿霉素肾病/tRNA衍生片段/足细胞损伤/细胞凋亡Key words
adriamycin nephropathy/tRNA-derived fragments/podocyte injury/apoptosis分类
医药卫生引用本文复制引用
徐明星,李善文,甘卫华,施会敏..tRFs在足细胞损伤与凋亡机制中的研究进展:以阿霉素肾病为模型的新视角[J].中国现代医学杂志,2026,36(11):56-62,7.基金项目
国家自然科学基金青年项目(82400864) （82400864）
南京市卫生科技发展专项资金项目(YKK23288 （）
YKK23289) （）
