中国药科大学学报2026，Vol.57Issue(3)：393-400,8.DOI:10.11665/j.issn.1000-5048.2025112103
中药治疗抗癌药物引发心脏毒性的研究进展
Research progress on traditional Chinese medicine in treating cardiotoxicity induced by anticancer drugs
摘要
Abstract
Cardiotoxicity induced by antineoplastic agents is an important factor affecting the prognosis of cancer patients.This article systematically summarizes the clinical manifestations of cardiotoxicity caused by chemotherapeutic drugs,molecular targeted cancer therapies,and immunotherapeutic drugs,and identifies the core injury mechanisms,including cardiomyocyte apoptosis,oxidative stress,and mitochondrial dysfunction.In Traditional Chinese Medicine(TCM)theory,anticancer drug-induced cardiotoxicity falls under the category of"heat toxins"characterized by dual deficiency of qi and blood,upward flaming of heart heat,stagnation of the heart vessels,and meridian obstruction induced by phlegm-dampness.Therefore,by reviewing the preventive and therapeutic effects and the underlying mechanisms of tonic medicines,interior heat-clearing medicines,blood-circulating and stasis-resolving medicines,phlegm-transforming,cough-suppressing and panting-relieving medicines,and interior-warming medicines,this paper concludes that TCM prevention and treatment of this condition adheres to the formulation principle of"reinforcing healthy qi,removing toxins,and resolving blood stasis".Its mechanisms of action—including antioxidation effects,regulation of autophagic balance,antagonism of inflammatory responses,and improvement of microcirculation—are highly consistent with modern medical treatment strategies(e.g.,dexrazoxane f or inhibiting iron-dependent oxidative stress,statins for anti-inflammatory effects).This study provides theoretical support and practical guidance for the collaborative and precise prevention and treatment of anticancer drug-induced cardiotoxicity through the integration of traditional Chinese and Western medicine.关键词
癌症/肿瘤心脏病/心脏毒性/中药/抗癌药Key words
cancer/cardio-oncology disease/cardiotoxicity/traditional Chinese medicine/anticancer drugs分类
医药卫生引用本文复制引用
苏琳玲,袁仙霞,江文瑜,莫岭,吴佳雪,王敏,刘东玲,海洋..中药治疗抗癌药物引发心脏毒性的研究进展[J].中国药科大学学报,2026,57(3):393-400,8.基金项目
国家自然科学基金项目(No.82260792) （No.82260792）
甘肃省青年人才项目(2025QNGR2) （2025QNGR2）
甘肃中医药大学研究生"创新创业基金"项目(2025CXCY-037) This study was supported by the National Natural Science Foundation of China(No.82260792) （2025CXCY-037）
the Project of the Special Foundation for Young Scientists of Gansu Province(2025QNGR2) （2025QNGR2）
and the Innovation and Entrepreneurship Program of Gansu University of Chinese Medicine(2025CXCY-037) （2025CXCY-037）
