中国当代儿科杂志2026，Vol.28Issue(6)：659-664,6.DOI:10.7499/j.issn.1008-8830.2512090
我如何治疗儿童热性感染相关性癫痫综合征
How I treat pediatric febrile infection-related epilepsy syndrome
摘要
Abstract
Febrile infection-related epilepsy syndrome(FIRES)mainly affects previously healthy children and adolescents,often leading to severe neurological impairment and long-term sequelae such as drug-resistant epilepsy and cognitive dysfunction.Based on two pediatric FIRES cases,combined with international and domestic guidelines as well as clinical experience,this paper highlights therapeutic strategies and escalation pathways tailored to different inflammatory phases in the acute and chronic stages.Incorporating continuous electroencephalogram monitoring and cerebrospinal fluid inflammatory cytokine profile changes,a phase-specific treatment approach is systematically described,centered on the rapid termination of status epilepticus,targeted cytokine immunotherapy,and multidisciplinary collaborative support,and the active use of tocilizumab,anakinra,and the ketogenic diet is emphasized,to provide practical guidance for clinicians in managing FIRES.关键词
热性感染相关性癫痫综合征/癫痫持续状态/诊断/免疫治疗/儿童Key words
Febrile infection-related epilepsy syndrome/Status epilepticus/Diagnosis/Immunotherapy/Child引用本文复制引用
邓小鹿,彭镜..我如何治疗儿童热性感染相关性癫痫综合征[J].中国当代儿科杂志,2026,28(6):659-664,6.基金项目
国家自然科学基金(82471488) （82471488）
湖南省自然科学基金(2026JJ80167) （2026JJ80167）
中南大学教改课题(2025jy203). （2025jy203）
