中国康复2026，Vol.41Issue(6)：353-357,5.DOI:10.3870/zgkf.2026.06.006
迷走神经磁刺激对脑桥梗死后吞咽障碍患者吞咽功能的影响
The impacts of vagus nerve stimulation on swallowing function and serum growth differentiation factor-15,C-reactive protein,and Visinin like protein-1 in patients with swallowing disorders after pontine infarction
摘要
Abstract
Objective:To explore the impacts of vagus nerve stimulation(VNS)on swallowing function and serum growth differentiation factor-15(GDF-15),C-reactive protein(CRP),and Visinin like protein-1(VILIP-1)in pa-tients with swallowing disorders after pontine infarction.Methods:From June 2024 to June 2025,80 patients with swallowing disorders after pontine infarction in our hospital were randomly assigned into an electrical stimulation group[using neuromuscular electrical stimulation(NMES)on the basis of routine swallowing rehabilitation train-ing,40 cases]and a magnetic stimulation group(using VNS on top of routine swallowing rehabilitation training,40 cases).The swallowing function,serological indicators,surface electromyography,and quality of life were com-pared.Results:After therapy,the scores of the standard swallowing function assessment scale(SSA)decreased in both groups,and the score of the magnetic stimulation group was prominently lower(P<0.01).After therapy,GDF-15,CRP,and VILIP-1 all decreased in both groups,and the indicators were prominently lower in the magnet-ic stimulation group(P<0.01).After therapy,both groups showed an increase in maximum wave amplitude and a decrease in swallowing duration,with the magnetic stimulation group showing more prominent changes(P<0.01).After therapy,the swallowing-quality of life scale(SWAL-QOL)increased in both groups,and the magnetic stimu-lation group scored prominently higher(P<0.01,0.05).Conclusion:VNS can effectively improve the swallowing function of patients with swallowing disorders after pontine infarction,reduce GDF-15,CRP,and VILIP-1,en-hance pharyngeal surface muscle function,and improve quality of life.关键词
脑桥梗死/吞咽障碍/迷走神经磁刺激/吞咽功能/GDF-15/CRP/VILIP-1Key words
pontine infarction/swallowing disorders/vagus nerve stimulation/swallowing function/GDF-15/CRP/VILIP-1分类
医药卫生引用本文复制引用
赵玉芹,刘耀庭,高月敏,田遂,吕学海..迷走神经磁刺激对脑桥梗死后吞咽障碍患者吞咽功能的影响[J].中国康复,2026,41(6):353-357,5.基金项目
邯郸市科学技术研究与发展计划(24422083035ZC) （24422083035ZC）
