中国当代儿科杂志2026，Vol.28Issue(6)：736-743,8.DOI:10.7499/j.issn.1008-8830.2507009
儿童单倍体造血干细胞移植后发生慢性移植物抗宿主病的免疫动力学特征与预测因素分析
Immune dynamics and predictive factors for chronic graft versus host disease following haploidentical hematopoietic stem cell transplantation in children
摘要
Abstract
Objective To investigate the immunological characteristics and predictive factors of chronic graft-versus-host disease(cGVHD)in children after haploidentical allogeneic hematopoietic stem cell transplantation(Haplo-HSCT)to provide a basis for early intervention.Methods A retrospective analysis was conducted on clinical and laboratory data of 64 children undergoing Haplo-HSCT.Peripheral blood lymphocyte subsets,immunoglobulins,and key components of the complement system were measured.Univariable and multivariable logistic regression analyses were used to identify predictors.Results The percentage of helper/inducer T lymphocytes and complement C3 levels were significantly higher in the cGVHD group(n=37)compared to the non-cGVHD group(n=27)(P<0.05),while the percentages of B cells and natural killer(NK)cells were significantly lower(P<0.05).Multivariate logistic regression identified the percentage of helper/inducer T lymphocytes(OR=1.144,P=0.012)and complement C3 level(OR=29.758,P=0.037)as independent predictors of cGVHD.Conclusions The development of cGVHD is closely associated with T-cell homeostasis imbalance,B-cell functional exhaustion,and abnormal activation of the complement system.The percentage of helper/inducer T lymphocytes and complement C3 levels may serve as potential predictive indicators for cGVHD occurrence.关键词
慢性移植物抗宿主病/单倍体造血干细胞移植/淋巴细胞亚群/体液免疫/免疫重建/儿童Key words
Chronic graft-versus-host disease/Haploidentical hematopoietic stem cell transplantation/Lymphocyte subset/Humoral immunity/Immune reconstitution/Child引用本文复制引用
唐冉冉,刘四喜,付笑迎,赵宇阳,李越,周小辉,陈诗杨,段秋悦,彭冬,邝雅贤,罗丽萍..儿童单倍体造血干细胞移植后发生慢性移植物抗宿主病的免疫动力学特征与预测因素分析[J].中国当代儿科杂志,2026,28(6):736-743,8.基金项目
深圳市科技创新委员会基础研究面上项目(JCYJ20210324142201004). （JCYJ20210324142201004）
