中国当代儿科杂志2026，Vol.28Issue(6)：763-767,5.DOI:10.7499/j.issn.1008-8830.2509140
儿童异基因造血干细胞移植后吉兰-巴雷综合征1例并文献复习
Guillain-Barré syndrome following allogeneic hematopoietic stem cell transplantation in a pediatric patient:a case report and literature review
摘要
Abstract
A 10-year-old girl diagnosed with hyper-IgE syndrome for more than six years developed dizziness and symmetrical progressive limb weakness one week prior to hospital admission,occurring 4 months after allogeneic hematopoietic stem cell transplantation.On post-transplant day 121,dizziness and progressive,symmetric limb weakness appeared.Cerebrospinal fluid analysis revealed albuminocytologic dissociation.Electromyography confirmed multiple peripheral nerve lesions,consistent with the diagnosis of Guillain-Barré syndrome.Intravenous immunoglobulin therapy showed limited efficacy,whereas corticosteroid therapy produced significant clinical improvement.Neurological symptoms fully resolved after treatment;however,severe chronic graft-versus-host disease occurred subsequently.Based on this case,related literature was reviewed and summarized to provide references for early diagnosis,mechanistic investigation,and treatment options.关键词
异基因造血干细胞移植/吉兰-巴雷综合征/移植物抗宿主病/儿童Key words
Allogeneic hematopoietic stem cell transplantation/Guillain-Barré syndrome/Graft-versus-host disease/Child引用本文复制引用
吕佳忆,周小辉,王春静,杨春兰,罗明静,刘四喜..儿童异基因造血干细胞移植后吉兰-巴雷综合征1例并文献复习[J].中国当代儿科杂志,2026,28(6):763-767,5.基金项目
深圳市医疗卫生"三名工程"(SZSM202211033) （SZSM202211033）
广东省高水平临床重点专科(深圳市配套建设经费)(SZGSP012). （深圳市配套建设经费）
