中国脑血管病杂志2026，Vol.23Issue(5)：329-338,10.DOI:10.3969/j.issn.1672-5921.2026.05.005
缺血性卒中铁死亡相关研究的文献计量学与可视化分析
Bibliometric and visual analysis of ferroptosis research in ischemic stroke
摘要
Abstract
Objective To analyze the current research status,hotspots,and trends of ferroptosis-related studies in ischemic stroke.Methods Literatures on ferroptosis in ischemic stroke published from database inception to December 8,2025 were retrieved from the Web of Science core collection.CiteSpace software was used to analyze publication output by country and institution,betweenness centrality(＞0.10 indicated an important bridging role),collaboration networks,keyword frequency,keyword co-occurrence,keyword clustering,and co-cited references.Results(1)A total of 413 publications related to ferroptosis in ischemic stroke in the Web of Science database were included,with the first related publication published in 2017.From 2017 to 2025,the publication output of ferroptosis-related publications in ischemic stroke showed a continuous and rapid upward trend.(2)A total of 21 countries published ferroptosis-related publications in ischemic stroke.China ranked first in publication output with 355 publications,followed by the United States(17 publications),Germany(7 publications),India(5 publications),and Canada,Japan,and the United Kingdom(3 publications each),ranking 2nd,3rd,4th,and 5th in publication output,respectively.The contributing countries formed a certain degree of international collaboration,among which Germany and the Netherlands had the highest betweenness centrality,both at 0.38,followed by Canada(0.34)and China(0.31),ranking 2nd and 3rd in betweenness centrality,respectively.(3)A total of 161 institutions published ferroptosis-related publications in ischemic stroke.The top 20 institutions by publication output were all from China.The top 10 institutions in order included Hunan University of Chinese Medicine(24 publications),Central South University(21 publications),Wuhan University(18 publications),Capital Medical University and Zhejiang University(17 publications each),Harbin Medical University(16 publications),Nanjing University of Chinese Medicine(15 publications),Sichuan University(14 publications),and Fudan University and Jilin University(12 publications each).Institutional collaboration was mainly domestic.The top 5 institutions in betweenness centrality were in order:the China Academy of Chinese Medical Sciences(0.45),Fujian Medical University(0.42),Guangzhou University of Chinese Medicine(0.38),Henan University of Chinese Medicine(0.37),and Nanchang University(0.34).(4)The top 10 keywords by frequency were oxidative stress(126 times),cell death(124 times),lipid peroxidation(100 times),iron(67 times),glutathione peroxidase 4(GPX4,41 times),apoptosis(31 times),inflammation(26 times),iron metabolism(20 times),iron overload(16 times),and autophagy(16 times).These high-frequency keywords showed close co-occurrence relationships in the included publications.Keyword clustering of related publications mainly included oxidative stress,blood-brain barrier,Acyl-CoA synthetase long-chain family member 4(ACSL4),ferroptosis suppressor protein 1(FSP1),and gastrodin.(5)The top 3 co-cited references were ACSL4 exacerbates ischemic stroke by promoting ferroptosis-induced brain injury and neuroinflammation,published in Brain Behavior and Immunity in 2021(123 citations),Ferroptosis:mechanisms,biology and role in disease,published in Nature Reviews Molecular Cell Biology in 2021(95 citations),and Ferroptosis:past,present and future,published in Cell Death and Disease in 2020(89 citations).Conclusions The publication output of ferroptosis-related research in ischemic stroke has shown sustained growth trend.China ranked first in publication output,while Germany and the Netherlands showed stronger connecting roles in the national collaboration network.Current research hotspots in this field mainly focus on oxidative stress,lipid peroxidation,iron metabolism,GPX4,and related cell death processes.Research directions such as oxidative stress,blood-brain barrier,ACSL4,FSP1,and gastrodin have received attention.关键词
缺血性卒中/铁死亡/CiteSpace/文献计量学/血-脑屏障Key words
Ischemic stroke/Ferroptosis/CiteSpace/Bibliometrics/Blood-brain barrier引用本文复制引用
韩雨薇,沙娜,霍达,巩顺,金海,朱廷准,李晓明..缺血性卒中铁死亡相关研究的文献计量学与可视化分析[J].中国脑血管病杂志,2026,23(5):329-338,10.基金项目
沈阳市脑血管病临床医学研究中心项目 （）
北部战区总医院自主科研项目(ZZKY2024063) （ZZKY2024063）
