中国脑血管病杂志2026，Vol.23Issue(5)：344-353,10.DOI:10.3969/j.issn.1672-5921.2026.05.007
皮质下梗死伴白质脑病的常染色体显性遗传性脑动脉病伴自发性脑出血的研究进展
Research progress on cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy with spontaneous intracerebral hemorrhage
摘要
Abstract
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL)is a common hereditary cerebral small vessel disease.Its typical clinical features include migraine with aura and recurrent ischemic stroke,while its potential manifestation of spontaneous intracerebral hemorrhage(ICH)is often overlooked.CADASIL patients with ICH have high rates of stroke recurrence,disability,and mortality,which significantly impacts their prognosis.This article systematically examined the epidemiological and imaging characteristics,risk factors,specific clinical manifestations,pathological mechanisms and treatment strategies for CADASIL with ICH,with the aim of providing a reference for the development of individualized management strategies in clinical practice.关键词
皮质下梗死伴白质脑病的常染色体显性遗传性脑动脉病/脑出血/基因突变/高血压病/脑微出血/综述Key words
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy/Intracerebral hemorrhage/Genetic mutation/Hypertension/Cerebral microbleed/Review引用本文复制引用
王宇洁,杜琳琳,吴明华,陈兆耀..皮质下梗死伴白质脑病的常染色体显性遗传性脑动脉病伴自发性脑出血的研究进展[J].中国脑血管病杂志,2026,23(5):344-353,10.基金项目
国家科技重大专项(2024ZD0522100) （2024ZD0522100）
