中国脑血管病杂志2026，Vol.23Issue(5)：354-362,后插1,10.DOI:10.3969/j.issn.1672-5921.2026.05.008
脑微循环障碍在血管性认知障碍中的作用机制及相关诊疗研究进展
Research progress on mechanisms of cerebral microcirculation disturbance in vascular cognitive impairment and novel strategies in clinical practice
摘要
Abstract
Vascular cognitive impairment(VCI)is the second leading cause of dementia after Alzheimer's disease.Due to its insidious onset and lack of specific treatments,VCI significantly impacts patients' quality of life.Microcirculation disturbance in the brain is a central pathophysiological process in the onset and progression of VCI.Key factors contributing to cerebral microcirculation disturbance include hemodynamic abnormalities caused by chronic cerebral hypoperfusion,microthrombosis,and inflammatory cascade reactions.Currently,detection methods for cerebral microcirculation disturbance are limited,and specific therapeutic targets are lacking.This article reviewed the role and pathophysiological mechanisms of cerebral microcirculation dysfunction in VCI,and aimed to help the screening of VCI and identify specific therapeutic targets for its treatment.关键词
血管性认知障碍/脑微循环/微循环障碍/慢性低灌注/综述Key words
Vascular cognitive impairment/Cerebral microcirculation/Microcirculation disturbance/Chronic hypoperfusion/Review引用本文复制引用
智小雨,王丽娟,高玉元,何培坤,聂坤,段青蕊..脑微循环障碍在血管性认知障碍中的作用机制及相关诊疗研究进展[J].中国脑血管病杂志,2026,23(5):354-362,后插1,10.基金项目
国家自然科学基金(82501438、82371249) （82501438、82371249）
