中国医科大学学报2026，Vol.55Issue(6)：512-516,5.DOI:10.12007/j.issn.0258-4646.2026.06.006
花椒麻素通过AMPK/ACC/SREBP1信号通路对妊娠期糖尿病大鼠的保护作用及其机制
Protective effect and mechanism of sanshool on rats with gestational diabetes mellitus via the AMPK/ACC/SREBP1 signaling pathway
摘要
Abstract
Objective To investigate the effects of sanshool on glycolipid metabolism and oxidative stress in rats with gestational dia-betes mellitus(GDM)via the AMPK/ACC/SREBP1 signaling pathway.Methods SD rats were randomly divided into control,model,low-dose sanshool,medium-dose sanshool,high-dose sanshool,and combined groups,with 12 rats in each group.Blood glucose,blood lipids,adipokines,and oxidative stress indexes were measured.Expressions of proteins related to the AMPK/ACC/SREBP1 signaling pathway were detected using Western blotting.Results Compared with the control group,the model group showed increased levels of fasting plasma glucose(FPG),fasting insulin(FINS),total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),leptin,malondialdehyde(MDA),and SREBP1,and decreased levels of high-density lipoprotein cholesterol(HDL-C),adiponectin(APN),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px),p-AMPKα/AMPKα,and p-ACC/ACC(P<0.05).Compared with the model group,the low-,medium-,and high-dose sanshool groups showed decreased levels of FPG,FINS,TC,TG,LDL-C,leptin,MDA,and SREBP1,and increased levels of HDL-C,APN,SOD,GSH-Px,p-AMPKα/AMPKα,and p-ACC/ACC(P<0.05).Compared with the high-dose sanshool group,the combined group showed increased levels of FPG,FINS,TC,TG,LDL-C,leptin,MDA,and SREBP1,and decreased levels of HDL-C,APN,SOD,GSH-Px,p-AMPKα/AMPKα,and p-ACC/ACC(P<0.05).Conclusion Sanshool may improve glycolipid metabolism and inhibit oxidative stress in GDM rats,potentially through activation of the AMPK/ACC/SREBP1 signaling pathway.关键词
花椒麻素/AMPK/ACC/SREBP1信号通路/妊娠期糖尿病/糖脂代谢Key words
sanshool/AMPK/ACC/SREBP1 signaling pathway/gestational diabetes mellitus/glycolipid metabolism分类
医药卫生引用本文复制引用
李丹,崔洪艳,韩哲辉,赵皤,刘静,程珦..花椒麻素通过AMPK/ACC/SREBP1信号通路对妊娠期糖尿病大鼠的保护作用及其机制[J].中国医科大学学报,2026,55(6):512-516,5.基金项目
天津市卫生健康科技项目(KJ20107) （KJ20107）
天津市医学重点学科(专科)建设项目(TIYXZDXK-039A,TJYXZDXK-043A) （专科）
