神经药理学报2026，Vol.16Issue(2)：50-57,8.DOI:10.3969/j.issn.2095-1396.2026.02.008
基于肠道菌群探讨药食两用类中药防治原发性骨质疏松的应用
Application and Mechanisms of Medicine-Food Homology Substances in the Prevention and Treatment of Primary Osteoporosis via Gut Microbiota Regulation
摘要
Abstract
Primary osteoporosis(POP)has emerged as a major chronic metabolic bone disease compromising the quality of life in middle-aged and elderly populations.It is pathologically characterized by progressive bone loss,microstructural deterioration,increased bone fragility,and a consequent elevated risk of fracture.This review examines the gut microbiota,considered the"second genome"in maintaining host homeostasis,which actively participates in the regulation of bone metabolism through multiple pathways—including the production of bioactive metabolites,modulation of immune-inflammatory balance,and preservation of intestinal barrier integrity—collectively forming the core regulatory network of the"gut-bone axis."Substances used in medicine and food homology offer a dual advantage,providing both nutritional support and pharmacological intervention.Their mild action and favorable safety profile make them particularly suitable for the long-term management required by chronic diseases.Emerging evidence suggests that these substances exert anti-osteoporotic effects through multi-target and multi-pathway mechanisms,such as remodeling the gut microbiota structure,optimizing the microbial metabolite profile,restoring intestinal barrier function,and regulating bone immune-inflammatory responses.This review systematically examines the intrinsic relationship between the gut microbiota and primary osteoporosis.It summarizes the current research progress and clinical applications of commonly used single-herb medicine-food homology substances and classical compound prescriptions in modulating the gut microbiota to intervene in POP.Finally,future research directions and emerging trends in this field are discussed,aiming to provide a theoretical basis and practical reference for the precision prevention and treatment of primary osteoporosis with traditional Chinese medicine and for the development and application of medicine-food homology resources.关键词
肠骨轴/肠道菌群/肠道微生态/药食同源/作用机制Key words
gut-bone axis/gut microbiota/gut microecology/medicine-food homology/mechanism of action分类
医药卫生引用本文复制引用
杨琦,江波,黄天慧,胡诚,周琨..基于肠道菌群探讨药食两用类中药防治原发性骨质疏松的应用[J].神经药理学报,2026,16(2):50-57,8.基金项目
国家中医药管理局第七批全国老中医药专家学术经验继承工作项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
