中国中西医结合急救杂志2026，Vol.33Issue(2)：236-241,6.DOI:10.3969/j.issn.1008-9691.2026.02.019
ICU患者谵妄药物防治研究进展
Research advances in pharmacological prevention and treatment of delirium in intensive care unit patients
摘要
Abstract
Delirium is a common acute cerebral dysfunction syndrome in critically ill patients,The incidence of delirium in intensive care unit(ICU)patients is as high as 50%to 80%.Delirium can lead to prolonged mechanical ventilation,ICU and hospital stays,increased mortality,and medical costs,as well as affecting long-term cognitive function.Because the pathophysiological mechanism of delirium is unclear,pharmacological prevention and treatment of delirium in ICU patients remains to be further explored.Common prophylactic medications for delirium include antipsychotics,dexmedetomidine,melatonin,statins,ketamine,and other agents,but current guidelines do not recommend any drug for routine prophylactic use against delirium.However,drugs used to treat delirium,such as antipsychotics,dexmedetomidine,clonidine,and valproic acid,have side effects and lack sufficient evidence.Currently,research on the prevention and treatment of delirium lacks clearly effective pharmacological agents,and further in-depth investigation remains necessary.关键词
重症监护病房/谵妄/药物/预防/治疗Key words
Intensive care unit/Delirium/Pharmacological interventions/Prevention/Treatment引用本文复制引用
何德华,王迪芬,刘旭..ICU患者谵妄药物防治研究进展[J].中国中西医结合急救杂志,2026,33(2):236-241,6.基金项目
国家重点研发计划项目(2018YFC2001904) （2018YFC2001904）
中华国际医学交流基金会中青年医学研究专项基金(Z-2018-35-2101) （Z-2018-35-2101）
贵州省科技成果转化及产业化项目(临床专项)(黔科合成果LC[2025]一般 133) National Key Research and Development Plan of China(2018YFC2001904) （临床专项）
Special Fund for Young and Middle-aged Medical Research of China International Medical Foundation(Z-2018-35-2101) （Z-2018-35-2101）
Guizhou Provincial Science and Technology Transformation and Industrialization Program(Clinical Special Project)(Qian Ke He LC[2025]General 133) （Clinical Special Project）
