中国中西医结合急救杂志2026，Vol.33Issue(2)：247-251,5.DOI:10.3969/j.issn.1008-9691.2026.02.021
巨噬细胞调控脓毒症免疫功能的机制与中西医干预研究进展
Research progress on the mechanisms of macrophage regulation of immune function in sepsis and interventions with traditional Chinese and Western medicine
摘要
Abstract
Sepsis is a life-threatening systemic inflammatory response syndrome triggered by infection.Its pathogenesis is complex,involving the abnormal activation and interaction across multiple systems and pathways.Despite advancements in critical care,its clinical mortality remains persistently high,posing a significant challenge in the field of intensive care medicine.As the first line of defense in the human innate immune system,macrophages serve as not only the core effector cells of innate immunity but also a critical bridge connecting innate and adaptive immunity.Throughout the entire process of sepsis onset,progression,and resolution,macrophages play an indispensable role in immune regulation.This review systematically explores the intricate interplay between macrophages and sepsis,focusing on the impact of macrophage dysfunction on overall immune function in sepsis and the underlying molecular and cellular mechanisms.The content primarily covers key aspects such as macrophage polarization imbalance,autophagy dysregulation,uncontrolled cell death,metabolic reprogramming,and other potential mechanisms.Through layered and multi-angle analysis of these mechanisms,this article aims to comprehensively elucidate the central role of macrophages in the immune imbalance of sepsis.This provides a solid theoretical foundation for future efforts to precisely and timely regulate macrophage function and restore host immune homeostasis.Additionally,it aims to explore innovative research directions and strategies for developing novel targeted therapies and interventions tailored to different pathological stages of sepsis,including the early hyperinflammatory phase and the later immunosuppressive phase.关键词
脓毒症/巨噬细胞/免疫功能/细胞死亡/代谢重编程Key words
Sepsis/Macrophages/Immune hunction/Cell death/Metabolic reprogramming引用本文复制引用
孙振琴,王彦君,苗开辉,董晨,靳佩,王昱..巨噬细胞调控脓毒症免疫功能的机制与中西医干预研究进展[J].中国中西医结合急救杂志,2026,33(2):247-251,5.基金项目
甘肃省自然科学基金项目(24JRRA550) （24JRRA550）
甘肃省兰州市城关区科技局项目(2023-11-5) Gansu Provincial Natural Science Foundation Project(24JRRA550) （2023-11-5）
Chengguan District Science and Technology Bureau of Lanzhou Project,Gansu Province(2023-11-5) （2023-11-5）
