摘要
Abstract
Objective:To investigate the effect of Rupatadine combined with Mometasone Furoate Nasal Spray in the treatment of allergic rhinitis and its influence on inflammatory response.Method:A total of 98 patients with allergic rhinitis admitted to NO.966 Hospital of the Joint Logistics Support Force of the Chinese People's Liberation Army from January 2023 to December 2024 were randomly divided into a single group and a combined group,with 49 cases in each group.The single group received Mometasone Furoate Nasal Spray treatment,while the combined group was treated with Rupatadine combined with Mometasone Furoate Nasal Spray,the treatment lasted for 4 weeks.Before and after treatment,inflammatory factors(TNF-α,IL-1β,IL-4),immune function[T lymphocyte subsets(CD3+,CD4+,CD4+/CD8+)],clinical symptom scores,ventilation function[peak expiratory flow(PEF),PEF day-night variability rate],and quality of life[rhinoconjunctivitis quality of life questionnaire(RQLQ)score]were compared between the two groups.Additionally,the incidence of adverse reactions was recorded.Result:After 4 weeks of treatment,the levels of TNF-α,IL-1β,and IL-4,scores for sneezing,runny nose,nasal congestion,nasal turbinate condition,RQLQ score,and PEF day-night variability rate in both groups decreased compared to those before treatment,and the values in the combined group were lower than those in the single group(P<0.05).After 4 weeks of treatment,the levels of CD3+,CD4+,and CD4+/CD8+and PEF in both groups increased compared to those before treatment,and the values in the combined group were higher than those in the single group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Rupatadine combined with Mometasone Furoate Nasal Spray can relieve the inflammatory response,enhance immune function,improve clinical symptoms and ventilation function,elevate the quality of life,and does not increase the incidence of adverse reactions in patients with allergic rhinitis.关键词
变应性鼻炎/糠酸莫米松鼻喷雾剂/卢帕他定/炎症反应/免疫功能Key words
Allergic rhinitis/Mometasone Furoate Nasal Spray/Rupatadine/Inflammatory response/Immune function分类
医药卫生
