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Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasia

Sunny H.Wong Marc T.L.Wong Louis H.S.Lau Rashid N.S.Lui Raymond S.Y.Tang James Y.W.Lau Simon S.M.Ng Jun Yu Joseph J.Y.Sung Thomas N.Y.Kwong Ru Zhang Thomas Y.T.Lam Andrew M.Y.Ho Wing Wah Leung Xing Kang Harry C.H.Lau Eagle S.H.Chu

癌症生物学与医学（英文版）2026，Vol.23Issue(5)：755-768,14.

癌症生物学与医学（英文版）2026，Vol.23Issue(5)：755-768,14.DOI:10.20892/j.issn.2095-3941.2025.0846

Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasia

Sunny H.Wong ¹Marc T.L.Wong ²Louis H.S.Lau ²Rashid N.S.Lui ²Raymond S.Y.Tang ²James Y.W.Lau ³Simon S.M.Ng ³Jun Yu ⁴Joseph J.Y.Sung ¹Thomas N.Y.Kwong ²Ru Zhang ⁵Thomas Y.T.Lam ⁶Andrew M.Y.Ho ²Wing Wah Leung ³Xing Kang ⁷Harry C.H.Lau ²Eagle S.H.Chu²

作者信息

1. Centre for Microbiome Medicine,Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore||Department of Gastroenterology and Hepatology,Tan Tock Seng Hospital,National Healthcare Group,Singapore 308433,Singapore
2. Institute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
3. Department of Surgery,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
4. Institute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China||CUHK-Shenzhen Research Institute,Shenzhen 518057,China
5. Institute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China||Shenzhen People's Hospital,Shenzhen 518020,China
6. The Nethersole School of Nursing,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
7. Centre for Microbiome Medicine,Lee Kong Chian School of Medicine,Nanyang Technological University,Singapore 308232,Singapore||Institute of Digestive Disease,State Key Laboratory of Digestive Disease,Li Ka Shing Institute of Health Sciences,Department of Medicine and Therapeutics,Faculty of Medicine,The Chinese University of Hong Kong,Hong Kong SAR,China
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摘要

关键词

Colorectal cancer/colorectal adenomas/colon carcinogenesis/colonic microflora/gut microbiome

Key words

Colorectal cancer/colorectal adenomas/colon carcinogenesis/colonic microflora/gut microbiome

引用本文复制引用

Sunny H.Wong,Marc T.L.Wong,Louis H.S.Lau,Rashid N.S.Lui,Raymond S.Y.Tang,James Y.W.Lau,Simon S.M.Ng,Jun Yu,Joseph J.Y.Sung,Thomas N.Y.Kwong,Ru Zhang,Thomas Y.T.Lam,Andrew M.Y.Ho,Wing Wah Leung,Xing Kang,Harry C.H.Lau,Eagle S.H.Chu..Comprehensive microbiome profiling reveals mucosal microbiome heterogeneity in patients with left-and right-sided colorectal neoplasia[J].癌症生物学与医学（英文版）,2026,23(5):755-768,14.

基金项目

The work was supported by the Singapore National Medical Research Council Clinician Scientist Individual Research Grant(Grant No.CIRG23jan-0004),Large Collaborative Grant(Grant Nos.OFLCG22may-0009,OFLCG23may-0031,and OFLCG24may-0025),and the Wang Lee Wah Memorial Fund. （Grant No.CIRG23jan-0004）

癌症生物学与医学（英文版）

ISSN：2095-3941

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