中国合理用药探索2026，Vol.23Issue(5)：38-43,6.DOI:10.3969/j.issn.2096-3327.2026.05.005
不同剂量布地奈德联合西替利嗪对支气管哮喘急性发作患儿Th17/Treg免疫平衡的影响
Effects of Different Doses of Budesonide Combined with Cetirizine on the Th17/Treg Immune Balance in Children with Acute Exacerbation of Bronchial Asthma
摘要
Abstract
Objective:To explore the efficacy of different doses of budesonide combined with cetirizine in the treatment of children with acute exacerbation of bronchial asthma,and its effect on the balance of peripheral blood helper T cell 17(Th17)/regulatory T cell(Treg)immune.Methods:A total of 96 children with acute exacerbation of bronchial asthma admitted to our hospital from March 2022 to January 2024 were prospectively enrolled and divided into control group and observation group by random number table,with 48 cases in each group.Both groups were orally administered cetirizine hydrochloride tablets.On this basis,the control group received 0.5 mg of inhaled budesonide suspension by nebulization each time.while the observation group received 1.0 mg of inhaled budesonide suspension by nebulization each time.Peripheral blood Treg and Th17 cell levels and their ratio,lung function indicators including forced expiratory volume in one second(FEV1),forced vital capacity(FVC)and FEV1/FVC,inflammatory factors including interleukin-6(IL-6),interleukin-10(IL-10),interleukin-17(IL-17)and transforming growth factor-β(TGF-β),as well as clinical efficacy and incidence of adverse reactions were compared between the two groups.Results:After treatment,Treg,FEV1,FVC,FEV1/FVC,IL-10 and TGF-β were increased in both groups,and were higher in the observation group(P<0.05);Th17,Th17/Treg,IL-6 and IL-17 were decreased in both groups,and were lower in the observation group(P<0.05).The total effective rate of the observation group was 95.83%,which was higher than 83.33%of the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compared with the inhalation of 0.5 mg budesonide,the combined inhalation of 1.0 mg budesonide and cetirizine in the treatment of children with acute bronchial asthma can significantly improve the clinical efficacy.regulate Th17/Treg immune balance,improve lung function and alleviate inflammatory response in children with acute exacerbation of bronchial asthma,without obviously increasing the risk of adverse reactions.关键词
布地奈德/西替利嗪/支气管哮喘/辅助性T细胞17/调节性T细胞/免疫调节/临床疗效Key words
budesonide/cetirizine/bronchial asthma/helper T cell 17/regulatory T cell/immune regulation/clinical efficacy分类
医药卫生引用本文复制引用
陈洋洋,马鸿琦,吴宗跃..不同剂量布地奈德联合西替利嗪对支气管哮喘急性发作患儿Th17/Treg免疫平衡的影响[J].中国合理用药探索,2026,23(5):38-43,6.基金项目
河南省医学科技攻关计划项目(LHGJ20211022) （LHGJ20211022）
