中国药科大学学报2026，Vol.57Issue(3)：288-294,7.DOI:10.11665/j.issn.1000-5048.2025081501
18α-甘草酸的合成工艺研究
Study on synthetic process of 18α-glycyrrhizic acid
摘要
Abstract
In this study,the synthetic process of 18α-glycyrrhizic acid was optimized.Using 18β-glycyrrhizic acid monoammonium salt as the starting material,the target compound 18α-glycyrrhizic acid was obtained through isomerization,esterification,and hydrolysis,with a total yield of 9.43%,purity of 99.23%and key impurity A of 0.17%(HPLC).The optimized process significantly improved the isomerization conversion rate,reduced the formation of related substances,simplified the purification steps,and enhanced both industrial scalability and cost efficiency.关键词
18α-甘草酸/合成/工艺优化Key words
18α-glycyrrhizic acid/synthesis/process optimization分类
医药卫生引用本文复制引用
李宇兴,马学燕,赵轲,赵佳星..18α-甘草酸的合成工艺研究[J].中国药科大学学报,2026,57(3):288-294,7.基金项目
This work was supported by the Science and Technology Program of Gansu Province(25CXGA029),and the National Natural Science Foundation of China(No.82560852)甘肃省科技专员专项(25CXGA029) （25CXGA029）
国家自然科学基金项目(No.82560852) （No.82560852）
