中国合理用药探索2026，Vol.23Issue(5)：93-99,7.DOI:10.3969/j.issn.2096-3327.2026.05.013
丙泊酚复合舒芬太尼对A型主动脉夹层动脉瘤手术患者免疫及神经功能的影响
Effects of Propofol Combined with Sufentanil on Immune and Neurological Functions in Patients Undergoing Type A Aortic Dissection Aneurysm Surgery
摘要
Abstract
Objective:To explore the effects of propofol combined with sufentanil on immune function and neurological function in patients undergoing type A aortic dissection aneurysm surgery.Methods:A total of 104 patients with type A aortic dissection aneurysm admitted from February 2022 to January 2025 were randomly divided into control group(sevoflurane combined with cisatracurium and sufentanil,n=52)and observation group(propofol combined with cisatracurium and sufentanil,n=52).Immune function indexes[CD4+,natural killer cell(NK cell),CD19+,CD4+/CD8+),neurological function indexes[glial fibrillary acidic protein(GFAP),neuron-specific enolase(NSE),myelin basic protein(MBP)]were detected before operation,6 h and 24 h after operation;Mini-Mental State Examination(MMSE)and Montreal Cognitive Assessment(MoCA)scores were evaluated before operation,12 h and 24 h after operation;the incidence of adverse reactions was compared between the two groups.Results:There were significant inter-group,time-point and interaction effects on immune function indexes,neurological function indexes and cognitive function scores between the two groups(P<0.05).At 6 h after operation,CD4+,CD4+/CD8+,NK cell and CD19+in the observation group were higher than those in the control group(P<0.05).The levels of GFAP,NSE and MBP at 6 h and 24 h after operation in the observation group were lower than those in the control group(P<0.05).The MMSE and MoCA scores at 12 h after operation in the observation group were higher than those in the control group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion:Propofol combined with sufentanil can alleviate immune function suppression and reduce neurological and cognitive function damage in patients undergoing type A aortic dissection aneurysm surgery,with good safety.关键词
丙泊酚/舒芬太尼/A型主动脉夹层动脉瘤/免疫功能/神经功能Key words
propofol/sufentanil/type A aortic dissection aneurysm/immune function/neurological function分类
医药卫生引用本文复制引用
杜守峰,韩冬,孙君隽,张正斌,梁行健..丙泊酚复合舒芬太尼对A型主动脉夹层动脉瘤手术患者免疫及神经功能的影响[J].中国合理用药探索,2026,23(5):93-99,7.基金项目
河南省医学科技攻关计划联合共建项目(LHGJ20210979) （LHGJ20210979）
