中国药科大学学报2026，Vol.57Issue(3)：322-331,10.DOI:10.11665/j.issn.1000-5048.2026022802
一株太子参植物内生真菌链格孢菌次生代谢产物的研究
Secondary metabolites of the endophytic fungus Alternaria alstroemeriae from Pseudostellariae Radix
摘要
Abstract
Sixteen compounds were isolated from the solid rice culture of the endophytic fungus Alternaria alstroemeriae WZ-419 derived from Pseudostellariae Radix,using silica gel,ODS,Sephadex LH-20 column chromatography,and preparative HPLC.Their structures were elucidated based on physicochemical properties and comprehensive spectroscopic analyses,and identified as alterpenoid A(1),tricycloalternarene A(2),altenusin(3),4'-epialtenuene(4),altenuene(5),alternariol(6),altenuisol(7),3-hydroxyalternariol-5-O-methylether(8),alternariol-9-methyl ether(9),alternariol 1'-hydroxy-9-methyl ether(10),stemphyperylenol(11),dihydroalterperylenol(12),alterinone A(13),4-hydroxy-3-methoxy-5-(2E,6E-3,7,11-trimethyldodeca-2,6,10-trien-1-yl)benzoic acid(14),hexylitaconic acid(15),and altechromone A(16).Among them,compound 1 and 13 were new,and compounds 14 and 15 were isolated from the genus Alternaria for the first time.The antibacterial a ctivities of compounds 1-16 were evaluated in vitro.Compounds 3,6-8,10,11,13,and 14 exhibited notable inhibitory effects against Gram-positive bacteria,with minimal inhibitory concentrations ranging from 8 to 64 µg/mL.This study isolated a series of antimicrobial metabolites from the endophytic fungi of Pseudostellariae Radix,providing new insights into their bioactive constituents and laying a foundation for further pharmacological investigations.关键词
太子参/内生真菌/链格孢菌/代谢产物/分离鉴定/抗菌活性Key words
Pseudostellariae Radix/endophytic fungus/Alternaria alstroemeriae/secondary metabolites/isolation and identification/antimicrobial activity分类
医药卫生引用本文复制引用
陆冰云,冯力,杨雯慧,龚远翔,汪哲,郝利君..一株太子参植物内生真菌链格孢菌次生代谢产物的研究[J].中国药科大学学报,2026,57(3):322-331,10.基金项目
国家自然科学基金项目(No.32300338,No.32470426) This study was supported by the National Natural Science Foundation of China(No.32300338,No.32470426) （No.32300338,No.32470426）
